Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
36 Cards in this Set
- Front
- Back
a patient has been overdosed with an irreversible AChE? how do you help them
|
1. maintain vital signs
2. remove patient from exposure 3. atropine 4. 2-PAM you can prolong the time to get help by giving a reversible AChE to block the binding site so the irreversible AChE wont bind |
|
a patient has a hard trauma with consequent damage to their parasympathetic sacral nerve? what drugs can you use to substitute?
|
cholinergic agonist
example: bethanechol |
|
what is the mechanism for succinylcholine
|
neuromuscular blocking agent
1. depolarizing the NMJ 2. desensitize the nAChR because AChE can't break it down |
|
when compared to rocuronium, tubocurarine...
|
|
|
what can be used to dephosphorylate AChE
|
PRALIDOXIME (2-PAM)
|
|
what is the mechanism for pilocarpine
|
activate parasympathetic organs secondary to stimulating ganglionic receptors
|
|
anticholinergic (atropine) should NOT be used for a gastric ulcer because
|
it is not selective for decreasing stomach acid production and it inhibits gastric acid being emptied from the stomach
|
|
reserpine acts by...
|
depleting the reservoirs of norepinephrine from the nerve terminal
|
|
cholinergic agents will have effects that overlap with
|
anticholinesterase drugs
|
|
propranolol is CONTRAINDICATED in patients with
|
NON SELECTIVE BETA BLOCKER
1. hyperthyroidism 2. congestive heart failure 3. asthma 4. diabetes |
|
mechanism by which phenylephrine treats paroxysmal atrial tachycardia is...
|
phenylphrine will increase blood pressure through stimulation of alpha 1 receptors, which leads to a reflex bradycardia
|
|
muscarine stimulates what receptor sites?
|
parasympathetic organs and tissues
|
|
what alpha antagonist binds IRREVERSIBLY to alpha 1 receptors
|
PHENOXYBENZAMINE
|
|
what is an anticipated effect of a beta 1 blocker (atenolol)
|
basically beta blocker effects
1. decreased heart rate 2. decreased renin release 3. decreased blood pressure 4. decreased contractility |
|
beta receptors would be expected to down regulate with the chronic administration of what
|
BETA AGONIST like albuterol
|
|
what are the beta 1 blockers
|
A.N.A.M.E
1. acebutolol 2. nebivolol 3. atenolol 4. metoprolol 5. esmolol |
|
what are the non selective beta blockers
|
1. propranolol
2. penbutolol 3. pindolol 4. carvedilol 5. labetalol 6. nadolol 7. timolol |
|
what is a CONTRAINDICATION of albuterol?
what other drugs have the same contraindications |
1. hypertension
2. coronary artery disease 3. congestive heart failure 4. diabetes TRAM: terbutaline, ritodrine, albuterol, metaproterenol |
|
what is a beta 1 agonist
|
dobutamine
|
|
what class of drug is isoproterenol
|
non selective beta agonist
|
|
the primary variable in the cardiovascular system that is controlled by the ANS is...
|
mean arterial pressure
|
|
what is norepinephrine selective for
|
alpha agonist
beta 1 agonist |
|
what is an alpha 1 agonist that can be administered systemically as a pressor agent
|
phenylephrine
|
|
what are the indirect acting sympathomimetics
|
1. amphetamine
2. methamphetamine 3. methylphenidate 4. pemoline |
|
what is the mechanism for phenylpropanolamine
|
induces catecholamine release
|
|
what are the cholinergic agonist?
|
esters:
1. acetylcholine 2. methacholine 3. carbachol 4. bethanechol alkaloids 1. muscarine 2. pilocarpine 3. nicotine |
|
what is the selectivity for phenylephrine and methoxamine
|
alpha 1 selective agonist
|
|
what is the selectivity for clonidine
|
alpha 2 selective agonist
|
|
what is the selectivity for norephinephrine
|
non selective alpha agonist
beta 1 selective agonist |
|
what is the selectivity for epinephrine
|
non selective alpha agonist
non selective beta agonist |
|
what is the selectivity for dobutamine
|
beta 1 selective agonist
|
|
what is the selectivity for isoproterenol
|
non selective beta agonist
|
|
what is TRAM?
|
beta 2 selective agonist
terbutaline metaproterenol albuterol ritodine |
|
what is phenotolamine
|
non selective alpha antagonist
|
|
what is phenoxybenzamine
|
alpha 1 antagonist
|
|
what drugs are alpha 1 selective antagonist
|
1. tamsulosin
2. prazosin 3. terazosin 4. doxazosin phenoxybenzamine not as selective as above |