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15 Cards in this Set
- Front
- Back
MOA
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Bactericidal
Binds to penicillin binding proteins which inhibit transpeptidase enzymes needed for cell wall crosslinking |
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Biliary tract excretion
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NAFCILLIN
AMPICILLIN |
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PEN G
SOA |
Common strep, meningococci, gram + bacilli, spirochetes
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PEN V
SOA |
Oral drug used mainly in oropharyngeal infxns
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Penicillinase resistant
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CLOXACILLIN
OXACILLIN NAFCILLIN DICLOXACILLIN (all Oral and parenteral) Methicillin (only parenteral) |
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Penicllinase resistant SOA
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Staph (usually staph. aureus)
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AMPICILLIN
AMOXICILLIN |
Same as PEN G and H. influenza, E. coli, Listeria monocytogenese, Proteus mirabilis, Salmonella, enterococci
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Anti-pseudomonas
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TICARCILLIN, CARBENICILLIN, PIPERACILLIN, MEZIOCILLIN, AZLOCILLIN
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B lactam inhibitors
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Sulbactam + AMPICILLIN
Clavulanic acid + AMOXICILLIN Clavulanic acid + TICARCILLIN Tazobactam + PIPERACILLIN |
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IMIPENEM
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Greater resistance to betalactamase
SOA - anaerobic, Gram +, Gram -, not for MRSA or C. difficile Given w CILASTATIN AE: seizures |
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MEROPENEM
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Beta-lactam Abx
Like IMIPENEM but doesnt require CILASTATIN and less likely to cause seizures |
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AZTREONAM
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Beta-lactam Abx
SOA: gonococci, pseudomonas, H. influenza AE: skin rash, nausea, vomiting, abnormal LFT |
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BACITRACIN
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MOA: interferes w isoprenyl phospate in cell wall synth
SOA: H. influenza, staph, strep, clostridium, slamonella, shigella, proteus, pseudomonas Use: furunculosis, impetigo, pyoderma, carbuncle, abscesses, suppurative & infective corneal ulcers AE: toxic for systemic use |
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VANCOMYCIN
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MOA: interferes w D-alanyl-D-alanine cell wall units
SOA: C. difficile, methicillin resistant staph & cocci Use: pseudomembranous colitis, pneumonia, empyema, endocarditis, osteomyelitis, abscesses AE: thrombophlebitis, redman or redneck synd, ototoxic, nephrotoxic, neutropenia |
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CYCLOSERINE
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MOA: inhibits conversion of L-alanine into D-alanine for cell wall synth
Use: 2nd line against TB resistant to streptomycin, 2nd line against CNS nocardia AE: pyschosis, convulsions |