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8 Cards in this Set
- Front
- Back
MOA of NSAIDs
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bind to cyclooxygenase to block synthesis of prostaglandins
*some MAY have LOX activity as well, but of minor importance |
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What alterations in the patient do NSAIDs treat?
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pain, inflammation, endotoxemia, fever, hypercoaguability
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What is the pathway for producing prostaglandins
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PLA2 liberates arachidonic acid from membranes
arachidonic acid metabolized by COX to form prostaglandins *COX competes with LOX, which forms leukotrienes |
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List the major ADEs expected with NSAIDs, and state why they are expected
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GI upset, ulcers/erosions, nephrotoxicity
"good" prostaglandins are in the stomach and kidney, and their protective function is eliminated by NSAIDs |
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What is the difference between COX 1 and COX 2?
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COX 1 tends to be constitutively expressed
COX 2 tends to have more proinflammatory effects *most NSAIDs have activity at both, just a matter of how much at each |
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What legal issues are associated with NSAIDs?
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phenylbutazone is illegal in mature dairy cows
Flunixin is the only NSAID approved for use in food animals Withdrawl times vary widely by species, cannot extrapolate WT or doses |
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Which NSAIDs are not labeled for veterinary use?
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aspirin, ibuprofen, naproxen, flurbiprofen, ketoprofen (allowed in horses)
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Which NSAIDs have special uses?
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flurbiprofen is only used in opthalmic preparations (approved for humans, but used in animals)
piroxicam is more commonly used in transitional cell carcinoma than as an NSAID |