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22 Cards in this Set
- Front
- Back
MHC complexes are found on what cells?
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antigen presenting cells
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MHC Class ___ contains 2 beta microglobulins and 2 alphas
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II
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MHC Class __ contains 1 beta and 3 alpha microglobulins
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I
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MHC Class ___ molecule binds 7-15 length peptides. MHC Class __ binds 10-30 length acid peptides
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I; II
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CD8 binds the ___ domain of the MHC Class ___ molecule
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alpha3; I
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CD4 binds the _____ domain of the MHC Class ___ molecule
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beta2; II
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exogenous antigen is presented in MHC Class __. Endogenous antigen is presented in MHC Class ___
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II; I
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____ genes are required for the transport of endogenous antigen into the ER for loading onto MHC
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TAP
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where are peptides that bind to MHC Class II molecules generated?
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in acidified endocytic vessels
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What is cross-presentation?
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when extracellular antigens are taken up and presented in the context of MHC Class I molecules in order to mount a cytotoxic CD8 T-cell response (major role in HIV)
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What prevents MHC class II molecules from binding to peptides while in the ER?
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invariant chain
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Most cells express MHC Class __ molecules
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I
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__ and ___ cells are the main expressors of MHC Class II molecules
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B; dendritic
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What are the only non-hematopoetic cells to express MHC Class II molecules?
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thymic epithelium
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MHC Class ___ deficiency is known as 'bare lymphocyte syndrome', resulting in severe combined immunodeficiency
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II
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what are HLA-A, HLA-B and HLA-C?
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the most polymorphic MHC Class I Human Leukocyte Antigens
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What are the most polymorphic Class II Human MHC's?
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HLA-DP, HLA-DQ and HLA-DR
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What is the advantage of being more polymorphic and polygenic for MHC?
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recognize and be able to fight off more antigens
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what does 'co-recognition' mean in the context of TCR's?
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TCR's recognize a complex of BOTH MHC and the peptide it holds
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What effect does polymorphism have of tissue transplants?
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high polymorphism increases the likelihood of transplant rejection
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What is the tissue most sensitive to MHC disparity?
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bone marrow
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What occurs in Graft vs. Host disease
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transplanted T-cells begin attacking the recipient's tissues
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