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31 Cards in this Set
- Front
- Back
What are the classws of immunotherapy agents?
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Immunoactivatiin, immunosupresion, vaccines and antibodies
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What are immune restoration drugs used for?
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Used for chemo-induced or drug-induced leukopenias.
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With which drugs must you monito the WBC count?
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ticlopidine, clozapine, propylthiouracil and chloramphenicol
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What is filgrastim? And what is its most common FX?
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G-CSF; bone pain
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Which form of G-CSF allow for 1 dose per chemo cycle and which needs 14 dails doses?
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pegylated-- 1 dose
nonpegy-- 14 |
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What is sargrmostim and whats its most common FX?
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GM-CSF; bone pain and flu-like syndrome
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Which agent is abused in long distance sports?
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erythropoietin
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What drug is used for treating anemias < 28 Hct?
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erythropoietin
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What sidw effects does EPO have?
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blood thickens -- clotting, strokes and MI
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Which agent are selective and don't inhibit the bone marrow?
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cyclosporine, sirolimus and tacrilimus
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What agent inhibits arachidonic acid formation?
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glucocorticoids
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How are glucocortioids classified?
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non-selective and anti-proliferative
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How does cyclosporin function?
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IL2 inhibition
cyclosporin + cyclophylin --> bind calcineurn and inhibit NFAT |
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Describe tacrolimus' MOA.
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Binds FK protein and inhibits calcineurin.
Inhibits IL2 |
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Describe sirolimus' MOA.
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Binds FK and block IL2 receptor.
also inhibits mTOR and locks cell in G1 phase |
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Which of the immune selectice agents have synergy together?
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sirolimus and cyclosporine
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Which if the selective agents is the least nephrotoxic?
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Sirolimus
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Kidney transplant pt taking cyclosporine, glucocortcoids amd basiliximab to prevent rejection, but inflammation continues 2 months later. What do you do?
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lower cyclosporine and add sirolimus (not as nephrotoxic).
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What are cytokine inhibitors?
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Monoclonal antibodies that directly inhibit cytokines/receptors.
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What are the contraindications for vaccines?
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Anaphylactic rxn to previous administration, live vaccines in immunocompromised pts, current disease.
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What is the TDap vaccine for and when do yoj give it?
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tetanus, diohteria and pertussis
2, 4, 6, 15 months and 4 years |
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What is the MMR vaccine for and when do you give it?
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measles, mumps and rubella
12 months, 4 years |
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Whe n do u give the varicella zoster vaccine?
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12 mo. and 2 for teens
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HepB
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at birth, 1 month, 6-9 months
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What is the PCV vaccine for?
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strep. pneumo
2, 4, 6, 12 months |
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When do you give the influenza shot?
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once a year beginning at 6 mo.
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What shot do you need to give 12 y/o?
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TDaP, meningococcal, HPV
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What types of flu vaccines are there?
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Quadrivalent inactivated and live-attenuated/trivalent (not for low immune pts)
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Which vaccine has a booster shot every 10 years?
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tetanus
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What shot is recommended for pts > 50 yrs?
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Herpes zoster
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HPV vaccine is against which strains? Ages?
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6, 11, 16, 18
as early as 9 yrs ; recommended is 11-26 yrs |