Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
17 Cards in this Set
- Front
- Back
What controls motility and secretory functions of intestines?
|
enteric nervous system
|
|
first line NTs in the gut?
|
dopamine, serotonin
|
|
MoA of metoclopramide
|
5-HT4-receptor agonist (enteric)
D2-receptor antagonist (enteric nerves, chemo-receptor trigger zone) |
|
Side effects of metoclopramide
|
extrapyramidal effects (lip smacking, ticks)
|
|
MoA of cisapride
|
5-HT4-receptor agonist
inc LES tone |
|
Side effects of cisapride
|
prolongs QT interval
cause arrhythmias when combined w/ P450 |
|
MoA of macrolide antibiotics
|
motilin receptor agonist
augments gastric and SB motility |
|
Side effects of macrolide antibiotics
|
diarrhea
|
|
MoA of ondansetron
|
blocks 5-HT3 at multiple sites (SB, vagal efferents, CTZ, Nucleus tractus solitarius) to suppress vomiting
effective for chemo-induced N/V |
|
Dopamine-receptor antagonist MoA
|
inhibit dopaminergic stimulation of CTZ
|
|
Uses of cannabinoid-receptor agonist
|
stim appetite, suppress vomiting
|
|
Antihistamine MoA
|
blocks H1 receptors
|
|
Side effects of antihistamine
|
drowsiness, dry mouth, blurred vision
|
|
MoA of loperamide
|
opioid, stim enteric, but not central, mu-opiod receptors
inc orocecal transit time & anal sphincter tone |
|
Side effects of using loperamide
|
can cause toxic megacolon, especially in C diff
|
|
MoA of diphenoxylate
|
opiod, stimulates enteric mu-opioid receptors
can penetrate CNS and stim central receptors |
|
Primary use of cholestyramine
|
cholerrheic diarrhea and adjunctive use in C diff
|