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30 Cards in this Set
- Front
- Back
reverse methotrexate with?
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leucovorin (folic acid)
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methotrexate weird toxicity
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macrovascular fatty changes in liver, mucositis
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recombinant GM-CSF used for myelorecovery / post transplant
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sagramostin
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G-CSF used to prevent/rx chemo-febrile neutropenia & promote myeloid recovery
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filgratin
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Oprelvekin
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recombinant IL-11, increases hematopoietic stem cells & megakaryocyte progenitor, used in thrombocytopenia
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5-FU moa and reversibility
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pyrimidine analogue (stops formation of t from u) blocks thymidylate synthase, reverse with thymidine
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6 mercaptopurine - moa, toxicity
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prodrug act by HGPRTase, block de novo syn, metabolized by xanthine oxidase so toxicity with allopurinol
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cytarabine - moa, use and weird SE
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inhibits DNA pol (crosses BBB), AML, megaloblastic anemia
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cyclophosphamide/ifosfamide: moa, weird side effect
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alkylating / cross linking at guanine N-7, needs liver activation; hemorrhagic cystitis (part prev w mesna)
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nitrosureas - name them, mechanism of action, special use, toxicity
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carmustine, lomustine, semustine, streptozocin
alkylate DNA, needs to be activated, crosses bbb RX brain tumors SE: pulmonary toxic, CNS tox |
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cisplatin, carboplatin - MOA, weird SE
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act like alkylating agents, nephrotoxic and acoustic nerve damage (drink more h20)
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busulfan - moa, use, weird se
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alkylates DNA, CML, pulmonary fibrosis, hyperpigmentation, cataracts
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mitomycin - moa
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ss breaks, hypoxic activation in tumor cells
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doxorubicin, daunorubicin - moa, weird SE, reversibility of SE
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free radicals + noncovalent interaclation in DNA
SE: cardiotoxic (use dexrazoxane), toxic extravastion |
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dexrazoxane - moa, purpose
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Fe chelator, decreases cardiomyopathy from doxorubicin
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dactinomycin - moa, use
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intercalate, act out > childhood tumors (wilm's, ewings, rhabdo)
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bleomycin - moa, unique use, weird SE
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free radicals / dna break, radiomimetic
use: skin / lung pulmonary fibrosis, skin changes |
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what's awesome about bleomycin?
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minimal myelosuppression
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hydroxyurea - moa
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inhbits ribonucleotide reductase/decreases DNA syn (s phase)
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noncancer use for hydroxyurea
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sickle cell
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etoposide: moa, use, weird SE
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G2 phase inhibits topoII / increases DNA degradation
use: SCLC, prostate, testicular carcinogen |
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Dacarbazine - moa, use, SE
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DNA methylation
met melanoma, osteosarcoma SE - carcinogenic, p450 |
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benefit of raloxifene over tamoxifene
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doesn't cause endometrial cancer - not an endometrial antagonist
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trastuzumab / herceptin SE
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cardiotoxic
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imatinib / gleevac - other uses, SE
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GI stromal tumor
fluid retention |
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imatibib - bind active or inactive site on Abl? what binds the other form?
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inactive ATP!
dastainib binds active form / more potent |
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whats awesome about vincristine
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less bone marrow suppression
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vincristine/vinblastine moa, se
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block polymerization of mt
vincristine - neurotoxic, paralytic ileus vinblastine - bone marrow suppression |
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taxols moa
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not soluble - G2/M phase prevent breakdown of mt spindles
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bevacizumab - moa, use
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VegFmab
colorectal, NSCLC met |