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20 Cards in this Set
- Front
- Back
where are the adrenal glands located?
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on top of the kidney
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what are the 2 main parts of the adrenal gland?
break down cortex and tell what is produced |
cotrex and medulla (medulla makes catecholamines)
zona glomerulosa (mineralcorticoids) zona reticulara (glucocorticoids) Zone fasiculata (androgens) |
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what is an example of a mineralcorticoid?
Glucocorticoid? |
aldosterone
Cortisol |
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what enzyme does the zona reticulars have that allows it to make androgens?
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cyp17
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what enzyme does the zona glomerulosa have that allows it to make mineralcorticoids?
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cyp11B2
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what regulates the zona fasiculata?
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ACTH
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what regulates the zona glomerulosa?
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ang II and extracellular K
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when glucocorticoids enter the blood they bind to what?
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Corticosteroid binding protein (CBP)
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what receptor does ACTH bind to on the zona fasiculata?
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melanocortin 2 receptor
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what 3 things do excess cortisol inhibit?
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the CRH receptor, release of CRH from the hypothalamus, and the release of ACTH.
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what does the binding of ACTH to melanocortin-2 do to StAR?
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increases StAR so you get more choelsterole into the mitocondria to make more glucocorticoids.
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what do glucocorticoids do for developing fetus?
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increase the production of surfactant.
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what kind of response does ANG II elict on the zona glomerulata?
what about extracellular k+ |
increase the expression of cyp11B2
increase the expression of cyp11b2 |
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what receptor does aldonsterone (mineralcorticoid) bind to?
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mineralcorticoid receptor (type1 GR)
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what is the enzyme in the kidney that keep cortisone from becoming cortisol?
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11 beta HSD
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what are some roles of mineralcorticoids?
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regulate K+, BP, regulate water and sodium,
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what does excess aldonsterone lead to?
why? |
HTN, due to increase uptake of na+ and water from the kidney.
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what are 2 ex of catecholamines produced by the renal medulla?
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epi and NE
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what 3 things cause an increase in secretion of catecholamines?
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ACTH, SNS stimulation, and cortisol
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what does vasostatin do?
Catestatin? |
- BV
- nicotinic ach receptors to dec stimulation of catecholamine release. |