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21 Cards in this Set
- Front
- Back
Two groups of bone resorption inhibitors?
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biphosphonates
selective estrogen receptor modulators |
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Name 7 biphosphonates?
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alendronate
etidronate ibandronate pamidronate risedronate tiludronate zoledronic acid |
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Name 1 selective estrogen receptor modulators?
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raloxifene
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What are the general uses of bone resorption inhibitors?
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primarily used to treat and prevent osteoporosis due to other causes including:
corticosteroid therapy treatment of Paget's disease of the bone management of hypercalcemia |
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Biphosphonates:
alendronate etidronate risedronate tilundronate these inhibit resorption of bone by inhibiting 1_______ _______ _____ and 2____ ____. |
1. hydroxyapatite crystal dissolution
2. osteoclast activity |
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Which agent binds to estrogen receptors, producing estrogen-like effects on bone including decreased bone resorption and decreased bone turnover.
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Raloxifene
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Contraindications?
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hypersensitivity
hypocalcemia |
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Raloxifene should not be used in women with child-bearing potential or a history of _______ disease.
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thromboembolic disease
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Use cautiously in patients with _____ impairment; some agents should be avoided in moderate to severe _____ impairment.
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renal
renal |
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______ supplements decrease absorption of biphosphonates.
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calcium
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Tilundronate's effects may be altered by aspirin or other ______.
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NSAIDs
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Aspirin may increase _______ adverse reactions with alendronate.
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GI
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Cholestyramine (increases, decreases) absorption of raloxifene (concurrent use contraindicated)
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decreases
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What assessments should be done?
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low bone density before and
during therapy symptoms of Paget's disease (bone pain, headache, decreased visual and auditory acuity, increased skull size) |
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What are the symptoms of Paget's disease?
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bone pain
headache decreased visual auditory acuity increased skull size |
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What are lab test considerations?
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monitor serum calcium in patients with osteoporosis...monitor alkaline phosphatase in patients with Paget's disease
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What serum levels should be monitored in patients with osteoporosis?
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calcium
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What serum levels should be monitored in patients with Paget's disease?
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alkaline phosphatase
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List 2 potential nursing diagnoses?
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Injury, risk for
Knowledge, deficient, related to disease processes and medication regimen |
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Instruct patient to take
medication exactly as directed Encourage patient to partici- pate in regular exercise and to modify behaviors that increase the risk of ______. |
osteoporosis
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EVALUATION:
Clinical response to therapy can be evaluated by? Prevention of or decrease in the progression of _____ in postmenopausal women. Decrease in the progression of _____ disease. |
osteoporosis
Paget's |