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42 Cards in this Set
- Front
- Back
Presence of Copper in blood was first recognised in |
1875 |
|
Found that traces of copper are essential for HB formation |
Hart and Elvehjem |
|
Adult body contains |
80g copper |
|
Highest conc of Cu is found in ____ followed by ____,___,____ and_____ |
Liver brain heart kidney and muscles |
|
In _____ and at _____ the conc of Cu is much high but decreases during _____ year |
Foetus , birth , first |
|
Cu is absorbed in |
Small intestine |
|
In Small intestine Cu ions are bound to _____ |
Metallothionein |
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Cu level in ____ regulate cu level in intestine |
Mucosal cells |
|
Net abs of cu varies from |
25-60% |
|
% of cu abs ____ with _____ intake |
Decreases , increased |
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About ___ % cu in blood plasma is bound as ___ complex known as _____ |
95 , protein , ceruloplasmin |
|
_____ also act as an enzyme to erythrocyte forming cell in bone marrow |
Ceruloplasmin |
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___% of cu is loosely bound in ___ and other proteins |
5 , albumin |
|
Cu is transported from blood in the blood to other tissue 1° bound to ____ |
Albumin |
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In ______ copper binds to metallothionein which serves as a ____ form for Cu |
Liver , storage |
|
Cu is trans from liver to other cells via |
Plasma |
|
Cu is transported from liver as a ___ which is major route of ____ of Cu |
Bile , Excretion |
|
Once Cu is in ____ cu becomes part of pool that may be ____ or ____ depending on need of cu |
Gastro intestinal tract , reabsorbed or excreted. |
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Small amount of Cu is also excreted via |
Urine , sweat , menstrual blood |
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Cu helps in formation of ______ by transporting Fe in transferring for ___ synthesis |
Hb , Hb |
|
Cu is required in many physiological function like (6) |
Erythropoiesis , skeletal mineralisation , CT formn , myelin formn , melanin pigment sun , oxid. Phosphorylation. |
|
________ enzyme which is _______ is required for oxidation of fatty acids |
Butyryl coenzyme , dehydrogenase |
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_______ is required for melanin pigment formation |
Tyrosinase |
|
_ is required for purine metabolism and also in ___ system for energy production |
Uricase |
|
Several Cu containing protein such as____ and ____ help to protect against toxic effects of oxygen |
Hepatocuperin and erthrocuperin |
|
___ may result from deranged iron metabolism |
Anemia |
|
Deficiency signs of cu include (4) |
Anemia vascular comp osteoporosis neurological manifestations |
|
Decrease in _____ leads to diminished collagen and ____ cross linking. |
Lysl oxidase , elastin |
|
Low blood level of cu is observed in _____ , ____ syndrome and ____ |
Kwashiorkar , nephritic syndrome and sprue. |
|
_____ is a malabsorption disease commonly found in tropical area marked with abnormal flattening of ____ and inflammation of the lining of _____ intestine |
Sprue , villi , small |
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Low serum can also lead to _____ syndrome |
Menke kinky hair syndrome |
|
Menke kinky hair syndrome is a condition characterised by (6) |
slow growth , degeneration of brain tissue , hypothermia , seizures , defective arterial wall and depigmentation of skin |
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Menke kinky hair syndrome results from ______ and ______ of cu and increased ______ of cu through urine |
Defective absorption , abnormal transport , increased excretion |
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____ is a poor animal source of cu |
Milk |
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______ , _______ and _____& are good plant sources of cu |
Legumes (soyabean) , oilseeds (sunflower , sesame ) , nuts (almonds) |
|
_____ are good animal sources of copper |
Seafood - oysters , crabs , lobsters , organ meats |
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______ & ______ are fair plant sources of cu |
Whole grains and fruits & vegetable |
|
______ are fair animal sources of cu |
Other meats |
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Excessive cu is toxic and seen in rare heredity condition called |
Wilson's disease |
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In Wilson's disease body fails to excereate excess cu leading to accumalation on _ , _ , _ , _ |
Liver , brain , kidney , cornea of eye |
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Exceess of cu nay lead to _ ,_ , _____disorders |
Hepatitis, renal malfunction , neurological |
|
A pure veg diet may help to reduce cu toxicity due to low copper content of ____ and ____ |
Fruits and vegetables |