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19 Cards in this Set
- Front
- Back
cell mediated immunity
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cells attacking cells
provided by T-cell lymphocytes |
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step 1
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antigen presenting cell phagocytizes antigen/pathogen (macrophage or monocyte or dendritic cell)
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step 2
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enters lymphatic tissue (lymph node)
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step 3
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presents antigen/pathogen to a population of T-cells
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step 4
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specific T-cells recognizes antigen
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step 5
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"activates"--> enlarges and undergoes many mitotic divisions to form a clone
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5) a. memory T-cells
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turned off and stored for later use
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5) b. helper T-Cells
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(CD4) required for both sides of immunity
secrete cytokines (interleukins 2,4,5) |
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5) c. Cytotoxic T-cells
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CD8, killer T-cells
-effector cell; leaves lymphatic tissue on a search and destroy mission |
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cytotoxic t-cells may estroy target cells/pathogens directly by secreting:
under c. |
granzymes
perforin granulyson lymphotoxin |
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granzymes
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protein-digesting enzymes; destroy target cells by releasing pathogens
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perforin
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protein channels; allow body fluid to enter the cell
cytolysis (cell rupture) |
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granulyson
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inserted into perforin channels to destroy pathogens
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lymphotoxin
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DNA fragmenting enzyme
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cytotoxic T-cells destroy target cells/pathogens in INDIRECTLY by secreting
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gamma interferon
macrophage migration inhibition factor |
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gamma interferon
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chemotactic agent for a variety of phagocytes; enhances phagocytes activity
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macrophage migration inhibition factor
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protein that prevents phagocytes from leaving the scene
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5). d. suppressor T-cells
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control cytotoxic T-cells
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5). e. hypersensitivity
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???
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