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18 Cards in this Set
- Front
- Back
Positive stains for PASH?
Cell of origin? |
Vimentin, ACtin, ER, CD34
Cell type: Myofibroblasts |
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5 features to distinguish sclerosing adenosis from tubular carcinoma?
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1 - lobulated arrangement
2 - compressed/distorted tubular lumens 3 - fibrous stroma compressing tubules 4 - two cell layers 5 - tubules invested by basement membrane |
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Which breast cancers have a better prognosis?
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Medullary, Mucinous, Tubular, Solid Papillary
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EIC Definition
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DCIS present involving at least 25% of the area of invasive carcinoma and extending outside the invasive carcinoma mass
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BRCA-1 Biomarker Profile
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ER, PR, HER2 -
CK 5/6+ |
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Which benign breast diseases have a 1.5 to 2.0 increased chance of breast cancer?
4.0 to 5.0? |
1.5 - 2.0: Florid hyperplasia, sclerosing adenosis, papilloma, complex sclerosing lesion
4.0 - 5.0: ADH, ALH |
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Five features to differentiate between benign and malignant phyllodes tumor?
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1. increased mitotic activity
2. marked atypia of stromal cells 3. stromal overgrowth 4. infiltrating margin 5. tumor necrosis and hemorrhage |
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Histologic features of radial scar?
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Stellate configuration
central elastosis and fibrosis entrapped ductules in the central scar dilated tubules at periphery various patterns of epithelial hyperplasia tubules lined by 2 layers of cells |
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Three benign breast conditions confused with invasive breast cancer?
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Sclerosing adenosis, microglandular adenosis, and radial scar
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Six Histologic Subtypes of DCIS?
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Solid, Comedo, Cribriform, Clinging, Papillary, Micropapillary
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Six types of IDC?
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Tubular, mucinous, medullary, invasive papillary, apocrine, metaplastic
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Luminal A phenotype?
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ER/PR +, Her 2 - good prognosis
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Luminal B phenotype?
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ER PR +, her 2 variable, not as good as A
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Her 2 phenotype?
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ER/PR - , her 2 + poor prognosis
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Basal like phenotype?
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ER, PR, HER2 - , receive platinum based chemo
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Two associated genetic abnormalities of ILC?
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LOH 16q (e-cadherin, beta catenin)
LOH 11q13 |
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ILC Hormone Stains?
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ER+, PR +, HER 2 -
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Paget disease stains vs Toker Cell hyperplasia
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Paget: Mucin +/-, CK7+, Cam 5.2+, EMA+, HER2 +
Toker: CK7 +/-, Mucin - , Cam 5.2 +/-, Her 2 - |