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53 Cards in this Set
- Front
- Back
The light-colored zone adjacent to the nucleus in a plasmacyte is the:
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golgi area
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The majority of the iron in an adult is found as a constituent of:
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2/3 of iron in body is bound to Hgb
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The main function of the hexose monophosphate shunt in the erythrocyte is to:
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provide reduced glutathione (to prevent oxidation of hemoglobin)
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Which hemoglobin chain is predominate in the fetus and continues to be even after birth?
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alpha polypeptide chain
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Which hemoglobin chain is present in low amounts the fetus but becomes one of the main hemoglobin chains after birth?
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beta polypeptide chain
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Which hemoglobin chain develops in high percentages during the fetal stage, but then drops after birth?
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gamma polypeptide chain
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Which hemoglobin chain is rare and can be present after birth?
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delta polypeptide chain
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Which hemoglobin chain is predominate during the beginning of the fetal stage but quickly drops?
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epsilon polypeptide chain
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In order for hemoglobin to combine reversibly with oxygen, the iron must be:
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in its functional form, ferrous
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What disease state is teardrop cells and abnormal platelets most characteristically seen?
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myeloid metaplasia (replacement of marrow with collagenous connective tissue fibers
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In the normal adult, the spleen acts as a site for:
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removal of imperfect and aging cells
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After removal of red blood cells from the circulation, hemoglobin is broken down into:
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iron, protoporphyrin, and globin
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Name: denatured hemoglobin inclusions that are readily removed by the spleen.
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Heinz bodies
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What hormone stimulates RNA synthesis of erythroid cells?
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erythropoietin
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What effect does spherocytes have on MCHC?
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increases MCHC
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What is a common characteristic of hereditary spherocytosis, hereditary elliptocytosis, hereditary stomatocytosis, and paroxysmal nocturnal hemoglobinuria?
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red cell membrane defects
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What effect does microcytic, hypochromic anemia have on serum iron, TIBC, and storage iron?
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serum iron and iron storage decreases and TIBC increases
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What is the reulting effect on iron due to chronic blood loss?
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iron deficiency anemia
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Evidence indicates that the genetic defect in thalassemia usually results in:
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RNA deficiency resulting in decreased globin chain production
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Describe G-6-PD deficiency.
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an enzyme deficiency associated with a moderate to sever hemolytic anemia after the patient is exposed to certain drugs and characterized by red cell inclusions formed by denatured hemoglobon.
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Peripheral blood smears from patients with untreated pernicious anemia are characterized by:
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pancytopenia and macrocytosis
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The characteristic morphological feature in folic acid deficiency is:
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macrocytosis
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Myelofibrosis, causing macrocytosis, is often accompanied by what?
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folic acid deficiency
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A characteristic morphologic feature in hemoglobin C disease is:
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target cells
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Thalassemias are characterized by a decrease rate of:
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decreased rate of globin synthesis
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True or False: Decreased osmotic fragility is associated with hereditary spherocytosis.
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false
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What type of polycythemia is a severely burned patient most likely to have?
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relative polycythemia associated with dehydration
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The characteristic morphologic feature in lead poisoning is:
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basophilic stippling
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What is the approximate mean value of a reticulocyte on specimens of cord blood from healthy, full-term newborn?
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5.0%
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A RBC about 5 micrometers in diameter that stains bright red and shows no central pallor is a:
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spherocyte
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What is the characteristic, morphological feature associated with accelerated heme sythesis?
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polychromatophilic, nucleated red blood cells and basophilic stippling
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The characteristic peripheral blood morphologic feature in multiple myeloma is:
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rouleaux formation
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In polychtemia vera, the hemoglobin, hematocrit, red blood cell count and red cell mass are:
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elevated
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The M:E ratio in polycythemia vera is usually:
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normal, increase in both myeloid and erythroid precusors
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A common source of interference in the cyanmethemoglobin method is:
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very high WBC count
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The most appropriate screening test for detecting hemoglobin F is:
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Kleihauer-Betke
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The most appropriate screening test for hemoglobin S is:
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dithionite solubility
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What is the formula and units for MCH?
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(Hgb x 10)/RBC
pg |
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What is the formula and units for MCHC?
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(Hgb x 100)/Hct
percent |
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What is the formula and units for MCV?
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(Hct x 10)/RBC
fL |
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What stain is used to identify siderotic granules?
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Prussian blue
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What and why is used to stain reticulocytes?
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new methylene blue, stains remaing RNA in the cell
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What stain is used to demonstrate iron, ferritin, and hemosiderin?
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Prussian blue
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What stain can be used to differentiate siderotic granules from basophilic stippling?
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Prussian blue
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True or False. Histiocytes contain hemosiderin.
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true
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Normal platelets have a circulating life-span of appoximately:
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9.5 days
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What drug affects platelet activity?
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aspirin
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In polycythemia vera, the platelet count is:
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elevated
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600e3/microleter of platelet count indicates what level of platelets?
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thrombocytosis
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Mucous membrane hemorrhages is characteristic of what?
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platelet disorders
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Considering platelets, what is characteristic of Bernard-Soulier syndrome?
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giant platelets
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A bleeding time is used to evaluate the activity of:
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platelets
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Platelet aggregation is dependent in vitro on the presence of:
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calcium ions
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