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18 Cards in this Set
- Front
- Back
How does warfarin work |
Inhibition of Vit K reductase (Vit K antagonist) Affects factors 2,7,9,10 |
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How is warfarin monitored |
INR aim 2.5 |
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Why is it important that warfarin also inhibits natural anticoagulants protein c and protein S |
Can occur within hours (unlike clotting factors which can take days) and cause hyper-coagulable state |
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How is warfarin metabolised |
Cytochrome P450 |
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How to reverse warfarin |
2-10mg IV Vit K Octaplex replenish factors 2/7/9/10 (25-50 units/kg) |
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How does heparin work |
Potentiates anti-thrombin Inactivatea thrombin and Xa |
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How is LMW heparin administered |
SC injection |
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How to administer Unfractionated heparin |
IV infusion |
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When are we most likely to use unfractionated heparin |
Patients with renal failure |
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What creatinine clearance must be reached to use LMW heparin |
30ml/min |
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Names of LMW heparin |
Tinzaparin 175U/kg Enoxaparin 1.5mg/kg |
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Rivaroxaban what does it inhibit |
Xa |
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What does dibigatran inhibit |
Thrombin |
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Dosing dibigatran |
110mg bd |
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Doing for rivaroxaban |
15mg bd |
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Action of aspirin |
Cycloxygenase inhibitor |
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Clopidigrel action |
ADP receptor blocker |
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Fibrinolytic agents |
Alteplase /TPA (tissue plasminogen activator)/ streptokinase |