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41 Cards in this Set
- Front
- Back
MCC of cancer related death in men or women
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lung
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MC CA in men and women
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breast and prostate
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T cells vs NK cells
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former need MHC complex to attack tumor
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Tumor markers for
Colon CA Liver CA Pancreatic CA testicular CA ChoriocCA Prostate |
CEA
AFP CA 19-9 CA 125 beta HCG PSA BRCA I and II NSE (small cell lung CA, neuroblastoma) |
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EBV is a/w what ttypes of CA
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Burkitt's lymphoma
Nasopharyngeal CA (c-myc) retroviruses contain oncogenes |
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Most vulnerable stage of cell cycle for XRT
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M phase
target DNA via oxygen radicals |
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Higher energy radiation has what effect
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skin preservation
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Fractionate doses
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allows repair of nl cells, tumor rexoygenation, and redistribution of tumor cells in cell cycle
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Very radiosensitive tumors
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seminomas
lymphomas |
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very radioresistant tumors
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epithelial
sarcomas |
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organs with increased sensitivity to XRT
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kidneys, lungs, liver, and lymphocytes
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Cell cycle specific chemo
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exhibit plateau in cell killing ability
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Tamoxifen
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decreases 5 year risk of breast CA by 45%
1% DVT 0.1% endometrial CA |
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MOA of Taxol
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microtubule formation --> rupture cells
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which 2 chemo agents cause pulmonary fibrosis
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bleomycin
busulfan |
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Adverse efx of cisplatin
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neuro, neuro, ototoxic
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Adverse efx of carBOplatin and vinBlastine
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BOne suppression
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2 microtubule inhibitor chemo agents
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Vincristine (peripheral neuropathy and neurotoxic)
vinblastine |
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MOA and AE of cyclophosphamide
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alkylating agent
acrolein is active metabolite AE SIADH, hemorrhagic cystitis (mesna can help) |
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MTX MOA
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DHFR inhibitor --> purine
nephrotoxic |
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role of leucovorin
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reverses effects of MTX by decreasing folate
increases toxicity of 5FU |
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MOA of 5FU
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inhibits thymidylate synthesis (purine)
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MOA/AE of doxorubicin
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DNA intercalater, oxygen radial
cardiotoxic |
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GCSF AE
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sweet's syndrome (acute febrile neutropenic dermatitis)
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Name 6 tumor suppressor genes
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Rb1
p53 APC DCC bcl BRCA |
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Name 5 proto-oncogenes and defects
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ras
src sis erb B myc |
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ras
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ras (G protein defect)
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src
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src (tyrosine kinase defect)
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sis
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sis (platelet derived growth factor receptor defect)
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erb B
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erb B (epidermal growht factor receptor defect)
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myc
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myc (transcription)
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Genetic defect in Li-Fraumeni syndrome and tumors
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p53
child sarcomas bresat CA brain tumors leukemia adrenal CA |
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Genetic defects a/w medullary CA of thyroid
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MENIN
Ret proto-oncogene |
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Genes a/w colon CA
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APC, p53, DCC, K-ras
does not go to bone |
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#1 CA to mets to axillary
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lymphoma (breast, melanoma)
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#1 CA to mets to bone
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breast
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#1 CA to mets to SB
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melanoma
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ovarian mets
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stomach and colon
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supraclavicular nodes
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neck
breast lung stomach pancreas |
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4 phases of clinical trials
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safe?
effective? better? implementation and marketing |
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5YSR of colon mets to liver
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25% if resected
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