The damage to the small intestine also makes it hard for your body to absorb vitamins, minerals, and other nutrients. This is because the villi is affected. The villi is affected due to the immune system mistakes a part of the body as an invader and the infection- fighting white blood cells begin attacking the lining of your small intestine. Due to an epithelial cell stress caused by gluten protein entering the small intestine, which then leads to increased expression of the IL-15, HLA-E, AND MIC antigens/cytokines. This increased expression causes and increase in the susceptibility of the CTL attack. Thus, causing epithelial cell killing, which is also known as the damaging of the villious atrophy. Also, the CD4+T tries to help the killing of the CTL so that the villi doesnt get damaged but most time it is not successful at killing the
The damage to the small intestine also makes it hard for your body to absorb vitamins, minerals, and other nutrients. This is because the villi is affected. The villi is affected due to the immune system mistakes a part of the body as an invader and the infection- fighting white blood cells begin attacking the lining of your small intestine. Due to an epithelial cell stress caused by gluten protein entering the small intestine, which then leads to increased expression of the IL-15, HLA-E, AND MIC antigens/cytokines. This increased expression causes and increase in the susceptibility of the CTL attack. Thus, causing epithelial cell killing, which is also known as the damaging of the villious atrophy. Also, the CD4+T tries to help the killing of the CTL so that the villi doesnt get damaged but most time it is not successful at killing the