adverse reactions 1.1 Introduction (QT prolongation) The toxicity of antipsychotic drugs is considered a good example of specific gender differences in Adverse Drug Reactions (ADRs) in a dose-dependent manner [1]. This adverse effect is induced cardiac arrhythmia known as torsade de pointes (TdP) (delay of cardiac repolarization), are associated with the following drugs such as; chlorpromazine, mesoridazine, pimozide and thioridazone, which increase the risk of QT prolongation. It also has…
The purpose of the research was to develop knowledge on the causes and complications of a prolonged QTc interval. The importance of looking at the research was developed because of a life threatening complication of a prolonged QT interval, torsades de pointes. Torsades de pointes is an arrhythmia that is characterized by the two lower heart chambers beating fast (Long QT syndrome, 2017). When this arrhythmia occurs, less blood is pumped out from your heart. If this arrhythmia is sustained…
consecutive R-R intervals (Gang & Malik, 2003). The predominant method for analysis of HRV is time and frequency domain analysis, and these measurements also provide information about ANS activity (Gang & Malik, 2003). Time domain analyses are calculated using mathematical equations, with measures reflecting parasympathetic modulation and circadian rhythmicity. The time domain measure utilized within this study is the standard deviation of all RR intervals…
The circulatory system is the system that transports nutrients, oxygen, carbon dioxide, hormone. It also helps fight disease, maintain body temperature, pH, and homeostasis. There are two systems that make up the circulatory system which are the cardiovascular system and the lymphatic system. The circulatory system moves blood through the body and is made up of the heart, blood vessels and the blood. The lymphatic system moves lymph to various parts of the body and is formed by the lymph, lymph…
direction. That said, an ECG provides four primary pieces of information for your doctor. First, an ECG can show how fast your heart is beating -- or more accurately, how fast the electrical activity is moving through your heart. By measuring the intervals between beats, your doctor can determine if the electrical signal is moving through your heart too slow or too fast. It also shows the strength and timing of the beat. By measuring the amount of electrical activity passing through your…
CHAPTER 2 2.1 ELECTROCARDIOGRAM The ECG Signal is a graphical representation of the electromechanical activity of system. The various propagation action potentials within the heart produce a current flow, which generates an electrical field that can be detected, in significantly attenuated form, at the body surface, via a differential voltage measurement system. The resulting measurement, when taken with electrodes in standardized locations, is known as the electrocardiogram. The ECG signal is…
the hypotension include central nervous system effects, skeletal muscle paralysis and depression of the carotid baro-receptor. Magnesium is also cardiotoxic. At serum Mg concentrations greater than 3 mmol/L, prolonged PR intervals, increased QRS duration and prolonged QT intervals are seen. Mild bradycardia is observed at concentrations greater than 7 mmol/L, and complete heart block as well as cardiac arrest may occur at concentrations greater than 7 mmol/L. Electrocardiographic changes in…
Mr. ABC came in to the emergency department (ED) with a chief complaint of left sided chest pain with giddiness and associated with diaphoresis the same morning. While in the ED, he developed a sudden episode of shortness of breath. Mr. ABC has nil past medical or surgical history and has an allergy to Enalapril. His parameters taken are as follows: • Blood pressure: 112 /60 mmHg • Pulse rate: 42 beats/min • Temperature: 35.9°C • Spo2: 97% on room air • Respiration rate: 17 breaths/min An…
Methadone is the second choice of pain relieving medication in the comfort kit (see comfort kit). This medication is used when a person has an allergy to morphine. We use it in hospice care as a pain reliever. The medication prolongs the QT interval and poses a risk to dysrhythmias. It should be monitored closes to patients who have cardiac issues. It is recommended that all patients received a ECG prior to treatment 30 days before and annually afterwards. All patients should follow the…
heart at rest. It provides information about your heart rate and rhythm and is used to assess multiple cardiac conditions. The purpose of this experiment is to determine the effect of exercise frequency on the duration and amplitude of the PR-interval, QT-interval, QRS complex, P-wave, and T-wave. If exercise frequency affects the duration and amplitude of the EKG reading, then the 3X or more exercise frequency will stimulate the heart to contract more vigorously due to the larger volume of…