Low-density lipoprotein

The low-density lipoprotein (LDL) receptor is an important protein in human function. LDL receptor is the main protein that binds and carries cholesterol to maintain homeostasis in mammalian cells. In human plasma, it is also the most abundant cholesterol-carrying lipoprotein (Goldstein and Brown, 1987). It plays a major role in the development of atherosclerosis, a chronic disease caused by the accumulation of LDL-cholesterol in the blood. The LDL receptor is also the main protein that is defective in individuals with familial hypercholesterolaemia, a genetic disease characterized by high levels of LDL cholesterol (Saha, et al., 2001). Individuals with familial hypercholesterolaemia generally develop cardiovascular complications and experience…

Everyone is going crazy with cholesterol these days. Health officials in the United States recommends that everybody over the age of twenty year’s old makes a cholesterol test once every five years (Mercola, " The Cholesterol Myth That Is Harming Your Health"). But, what is cholesterol and why is it so important? First of all, some concepts need to be explained. Cholesterol is often mistaken with triglycerides. Both are types of lipids (fats) (Matters). Both are transported in the body by…

liver but can also get from animal and milk products in the diet. Considered a steroid, a lipid and an alcohol, cholesterol has so many functions in the human body that are unavoidable. Cholesterol are of two types which include good cholesterol and bad cholesterol. You may be wondering what all the confusion is about good and bad cholesterol. Is good cholesterol really good or is it just a “not-so-bad” form of cholesterol that isn’t as problematic as bad cholesterol? It is actually the first…

has been linked to dietary patterns. Diets high in cholesterol and saturated fats promote atherosclerosis and increase levels of blood cholesterol. Increases in blood pressure levels are also related to diets high in salt or sodium. Consumption of an excess amount of animal products – such as meat and dairy products – that contain saturated fats can increase low-density lipoprotein cholesterol in the body. When the body has too much low-density lipoprotein cholesterol, this cholesterol begins to…

just like general body health, depends on the types of foods you eat. There are a number of diet-related risks, including high cholesterol levels, diabetes and obesity. An individual’s choice of foods can either increase his risks of coronary heart disease, or protect him from it. For example, certain types of fat consumed, like saturated fats or trans fats, can increase blood cholesterol and heart attacks, whereas polyunsaturated and monounsaturated fats lower the risk of heart attacks…

Michelle DeSanti Biology 22 (24556) Professor Linder 4 May 2017 Clinical outcomes: Evolocumab use for Cardiovascular Disease High cholesterol, two words that can certainly ignite a fear in a patient who is newly diagnosed with this common issue. Which brings us to the question, what exactly is high cholesterol and what makes it so bad? Low-density lipoprotein cholesterol, also known as LDL cholesterol is what many consider to be the “bad cholesterol”. This is due to the fact that LDLs bring fat…

out functions such as vesicle formation, movement of the vesicle or tethering a vesicle to a membrane. A GTPase activating protein (GAP) hydrolyses GTP to GDP, by losing an inorganic phosphate group, to inactivate it once again. A guanine nucleotide dissociation inhibitor (GDI) removes the attachment of the Rab protein from the membrane. The GDI dissociation factor (GDF) is used to dissociate the Rab protein from the GDI for recycling (Hutagalung and Novick, 2011). Rab prenylation is vital for…

Saturated fats (SFA), commonly found in animal fats that we consume, has been shown to increase one’s low-density lipoprotein (LDL) cholesterol by inhibiting LDL receptor activity need for LDL uptake by cell (increasing in blood LDL) and increasing LDL production. This increase in LDL causes it to deposit in the walls of arteries forming plaques; therefore, increasing risk of cardiovascular disease (CVD). By lowering the consumption of SFA, it decreases one’s risk of a cardiac event by…

narrowing and hardening of arteries), a very common reason for heart attack and stroke by consuming the right type of foods. You should incorporate many healthy food items into your breakfast, lunch, as well as dinner on a regular basis to keep the heart functioning perfectly. A heart-healthy diet plan never includes harmful fats, sodium, and bad cholesterol and is full of whole grains, lean proteins, fruits, and vegetables. In the subsequent paragraphs, we will mention the top 10 super foods…

Accepting criticism is not easy to do for anyone. We are taught at an early age that if you don’t have anything nice to say then don’t say anything at all. So when someone is criticizing you it is hard to consider it thoughtfully because it is usually considered something bad. This is not always the case, it is healthy to receive constructive criticism about ourselves and it is how we grow as individuals. Everyone is not perfect and it is okay to realize that we all have faults and I have…