Lonidamine was developed by Threshold Pharmaceuticals in 1979. [5] Lonidamine was derived from indazole-3-carboxylic acid. [4] When originally discovered, Lonidamine was used as an infertility drug. [4] Through later research, Lonidamine was seen to have desirable effects on cancer cells. Lonidamine was then used as a drug for benign prostatic hyperplasia. Benign prostatic hyperplasia is the enlargement of the prostate gland in males. This causes symptoms like discomfort, frequent urination, and difficulty urinating. [1] This can be caused by prostate cancer. Lonidamine inhibits the hexokinase enzyme, thus leading to the inhibition of glycolysis. The purpose of glycolysis is to convert glucose into two pyruvate molecules that can be converted…
Bentyl (dicyclomine) is an anti-spasmodic drug which relaxes the muscle in the wall of the gut. It can reduce the intestinal contractions of an irritable bowel and therefore reduce pain and diarrhea. Bentyl comes in the forms of capsule, tablet, and oral liquid. It is usually taken four times per day. For best results, Bentyl should be taken 30 minutes to 1 hour before eating a meal. Bentyl should not be taken at the same time as an antacid. Some Antacids can reduce the effectiveness of Bentyl.…
L., Catalano, 1993). It is less expensive compared to octreotide and is taken orally (PO), which is convenient for patients being treated on an outpatient basis. In comparison, octreotide is given as an injection subcutaneously (SQ), intramuscularly (IM,) or via a continuous intravenous infusion (IV) (Cascinu et al.), it cannot be given in oral form. Octreotide is a somatostatin mimicking growth hormone inhibitor that is known to slow intestinal activity, like loperamide it inhibits…
anger, and depression often develop from the realization that opioids are firmly in control and won’t let the addict go free. In some cases, a non-medically supervised detoxification can be dangerous: • Extensive sweating, vomiting, and diarrhea can lead to dehydration. Dehydration can then lead to medical complications, such as an electrolyte imbalance, a drop in blood pressure, or an arrhythmia. • Detoxifying from benzodiazepines or alcohol while also detoxifying from opioids can lead to…
Emotional stress is the leading cause of IBS. FACT: The cause of IBS is unknown, but, in many patients, stress triggers symptoms. For these patients, identifying the psychosocial stressor and using techniques such as relaxation therapy, stress management, hypnosis, and cognitive behavior therapy may help reduce abdominal pain and diarrhea. MYTH: A simple treatment plan is available to patients suffering from IBS. FACT: Because IBS symptoms vary among patients, no standard protocol has been…
passage of Sarbanes Oxley Act III. raising of public policy issues IV. promise of implied-contract or covenant-of-good-faith Answer Selected Answer: I, II, III, IV Correct Answer: I, II, III, IV Question 7 4 out of 4 points Correct What was the majority ruling on the wrongful termination allegations of Dr. Pierce in her case against Ortho Pharmaceutical Corp.? Answer Selected Answer: She…
inflammation in ulcerative colitis, then manipulating colonic bacteria as a therapy makes sense. However, antibiotics such as Flagyl (Metronidazole) have shown minimal clinical benefits in ulcerative colitis and are not routinely used. Even though MsV blood result showed elevated WBC which was 12,000mm3 according to (Cunningham et al., 2005), the normal non-pregnant WBC ranges from 5,000 to 10,000 mm3. During pregnancy, the WBC increases, ranging from 5,000 to 12,000 mm3. On admission MsV was…
coats and softens the stool ,preventing the colon from absorbing water Skin rashes Decreases absorption of ADEK Acute constipation, Chronic constipation, Softens faecal impaction 4 Hydrating agents Hydrating agent increases bowel movement osmolarity, increases amount of water in stool and making it easier to pass. Electrolyte imbalance Nausea, cramping Bloating, flatulence Colonoscopy Surgeries X-rays anthelmintic 5 stimulants Stimulates the contraction of the colon making it easier to…
not take any nutritional supplements. Height: 5feet 5inches Weight: 118lbs. Usual body weight: 128lbs. Laboratory findings: within normal levels Medications: none pertinent 1. Describe the patient’s nutritional requirements. The patient`s with Chorn`s disease require low-fiber food to decrease symptoms. Also it is important to receive vitamin and mineral supplement to increase the level of vitamin B12, folic acid and iron. 2. Identify the nutrition diagnosis and intervention(s). ZW needs…
better depending on what day of my detox I was on. Taking it with the Clonidine will make you feel even better, so you want to get to your doctor. People have detoxed off of everything from Oxy 's to heroin to dilaudid using Kratom. Others have reported that did nothing to alleviate their discomfort. There was a study done by Mass General Hospital back in 2008. A man had been using 10mgs of Dilaudid and became addicted, he then used Kratom to keep his withdrawal to a minimum. The doctors were…