Apoptosis

Bacillus anthracis is the causative organism of the serious infectious disease, called anthrax. There are three manifestations of this disease. The manifestations include gastrointestinal anthrax, inhalation anthrax, and cutaneous anthrax. This research will explore the morphology, virulence factors, reservoir, transmission, and portal of entry of B. anthracis. The pathogenesis will also be reviewed, including symptoms, how B. anthracis causes these symptoms, the possible complications of the…

Tooth agenesis - non formation of the tooth is the most common dental anomaly seen by a dental practitioner. The overall prevalence of this anomaly excluding 3rd molar is 6.4%. But the prevalence varies depending upon the continent – highest of 13.4% in Africa to the lower prevalence of 4.4% in Latin America and Carribbean and it is 1.22 times more prevalent in females1. Congenital missing teeth fewer than 6 teeth are known as hypodontia whereas absence of more than 6 teeth is called as…

TAZ gene, is a mitochondrial membrane-associated protein that remodels cardiolipin (CL), an important mitochondrial phospholipid. CL is essential for proper mitochondrial structure and function, ensuring proper functioning of energy production and apoptosis. TAZ mutations are associated with the X-linked metabolic disorder, Barth syndrome (BTHS). BTHS is a lipid metabolic disorder that affects mitochondria that is often fatal in infancy and early childhood, due to heart failure and life…

the details of the gene's involvement are still being researched. EHBP1 is primarily known as a marker for prostate cancer. EHBP1 is involved in the proper functioning of nuclear AKt, a protein kinase that is involved in apoptosis. A change in EHBP1 may cause issues with apoptosis, which can lead to a tumor. The type of cancer associated with defects or variations in the EHBP1 gene is prostate cancer. The type of prostate cancer is called, "Prostate Cancer, Hereditary, 12." EHBP1 is associated…

knocked out there is no regulation of proliferation, mutations of TP53, a tumor suppressor gene, occurs in only 3% of patients that have ALL (Gallegos-Arreola et al., 2013). A third hallmark is evading apoptosis; types of genes common to be knocked out are from the NOTCH family, since they inhibit apoptosis stimulated by p53 allowing the tumor to worsen,” (Gallegos-Arreola et al., 2013). The fourth hallmark is limitless replication, meaning nothing can stop the growth of the tumor (Huether &…

The enrichment of Role of Deleted in Colorectal Carcinoma (DCC) in regulating apoptosis signal transduction pathway was an important finding that indicated the role of Dapk1 in colorectal carcinoma through regulation of ligand-independent caspase activation (Forcet, et al., 2001). The pathways related to Notch signaling were the next…

acting as a chain-breaking antioxidant (Reason et al., 2011). It suppresses the activation of NF ƙB, an inducible transcription factor that regulates expression of anti-apoptotic genes and induces metastasis (Garg and Aggarwal, 2002) thus increases apoptosis as observed in the current…

By Shamik D. Majumdar What does cancer cell mean? Normal cells can repair themselves if any part gets damaged . This process is known as DNA repair. If the damage is too bad, they will self slaughter- known as apoptosis. (1) The molecules in cancer cells decide whether a cell should repair itself or not .EX: “a protein called p53 normally checks to see if the genes can be repaired or whether the cell should die”, so basically it decides to repair itself. But many…

very good cytotoxic agents against different types of cancer cell lines. 8 Recently bisbenzimidazole conjugates have been reported to target mitochondria in cancer cells and induce their antiproliferative activity by caspase 2,3 Most dependent apoptosis. 9 50…

Infiltration of macrophages is commonly observed in both forms of advanced AMD. Activated macrophages can induce death of RPE by activation of the complement cascade or induce apoptosis by a contact dependent mechanism [14, 15]. Based on functions, cytokine profiles, and surface markers, macrophages can be classified as M1 (pro-inflammatory) and M2 macrophages (pro-angiogenic). These two types of macrophages carry out distinct biological…