Anthracycline

• Acute myeloid leukemia (AML) is a type of cancer that affects the bone marrow and the blood. It disrupts the normal bodily production of the white blood cells, red blood cells and platelets. • Acute simply means it is fast growing, therefore fatal if not treated quickly. Myeloid refers to the lineage it comes from. As for AML, it is from the myeloid lineage. And lastly leukemia is the disease of the cancer of the blood cells from the bone marrow. AML are caused by various factors but primarily is due to the mutation. As for AML, there are 2 possibilities; 1. Mutation to the signaling pathway: Signaling pathway is the body’s form of communication. A disruption in the pathway would lead to wrong information being relayed. An example in AML…

studies demonstrate that cardiomyocyte death through apoptosis, necrosis, and other forms is a primary contributor to the development of DOX-induced cardiomyopathy(Zhang et al.,2009) The anthracycline doxorubicin-induced myocyte apoptosis is mediated by oxy radical chemistry. and change in level of antioxidant in the heart tissues(increase in CAT ,SOD and decrease level of GSH). On the other hand, a significant increase was observed in GSH levels, SOD and CAT activities in liver in the…

Eribulin mesylate (Halaven, Eisai), an FDA approved drug for use in late stage breast cancer is now concurrently indicated for the treatment of soft-tissue sarcoma (STS) that is inoperable or has metastasized known as liposarcoma. Eribulin mesylate can now be used in patients who have previously received anthracycline chemotherapy as treatment for liposarcoma. Liposarcoma is difficult to treat; most patients tend to have resection of malignant cells or curative surgery. Tumor cells are removed…

Regimens used in the ductal subtype can be used in the same way (21). Some studies showed an advantage in using anthracycline based chemotherapy in NEBC (22), whereas others didn’t show this benefit (2) (14). Some reports recommended the use of anthracycline based chemotherapy according to Ki-67 expression, usually if ki-67 is around 10%. For poorly differentiated carcinomas, especially the small cell subtype where ki-67 is more than 15% , cisplatin / etoposide is recommended as used in small…

retention and hypersensitivity reactions. ? For patients who have not previously received chemotherapy for metastatic or inoperable locally recurrent HER2- negative breast cancer, in combination with bevacizumab Breast cancer in females ? Docetaxel Solution for injection; Adults (18+ years): 100 mg/m2 IV on day 1 with bevacizumab (15 mg/kg IV, day 1), repeat q3 weeks; has been given up to 9 cycles, with bevacizumab continued until disease progression or unacceptable toxicity. In phase III…

Cox proportional hazard models were used to assess the relationships between the treatments of breast cancer and the development of the heart condition diagnosed by a doctor after chemotherapy. Age was a time-to-event variable for validity while comparing those diagnosed with cancer to those without cancer provided statistical control. The study results concluded there is a 1.4 fold increase in cardiac disease and cardio toxicity from chemotherapy for breast cancer. In a number of the…

Cancer is one of the most important human health problems in the world. There is a global effort to make progress in new technologies that could overcome the inherent disadvantage of chemotherapy and efficiently destroy tumors without damaging the healthy body. The two most important goals of antitumor therapy are to detect cancer at primary steps, deliver medicinal active ingredients to the special sites with reducing of adverse effects and increase of the efficacy of an anticancer drug. One of…

substrates both in the in vitro and in vivo bioconversion experiments, 7,8-dihydroxyflavone showed significant product conversion and was further analyzed by NMR study and confirmed as 7-hydroxy 8-O-methoxyflavone. Fermentation bioconversion assay was also performed with 7,8-DHF. Moreover, while analyzing the in vivo reaction mixtures by HR-QTOF-LC-ESI/MS, the mass fragments of O-methyl 3-hydroxyflavone, O-methyl phloretin, O-methyl luteolin, three mono- di- and tri-methylated genisteins,…

surgery. Chemotherapy has been shown to be as effective form of treatment as a neoadjuvant therapy (a neoadjuvant therapy is a preliminary treatment given to decrease the size of the tumor before surgery is given) (Isakoff, 2010). In many cases radiation therapy is given post-surgery to try to decrease the risk of reoccurrence (NCI, PDQ). For chemotherapy anthracyclines (a class of chemotherapy drugs developed from a bacteria known as Streptomyces peucetis var. caesius) are generally used.…

urgent need for new treatment options for patients with PTCL, especially those with recurrent or refractory disease, who typically have limited responses to salvage therapy and extremely poor OS.9 (art 2) 1.b Options of Therapies for Peripheral T-Cell Lymphomas Frontline treatment of peripheral T-cell and NK-cell neoplasms is dependent on the subtype of disease and often includes clinical trials as the preferred therapeutic options (NCCN 2013). For most subtypes, anthracycline-based multiagent…