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16 Cards in this Set
- Front
- Back
Name all the nephritic syndromes
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1. Acute poststreptococcal glomerulonephritis
2. Rapidly progressive glomerulonephritis (crescentic) 3. Diffuse proliferative glomerulonephritis 4. Berger's Disease 5. Alport's Syndrome (also has ESRD and hearing loss b/c of poorly formed basement membranes) |
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Name all the nephrotic syndromes
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1. Membranous glomerulonephritis
2. Minimal Change disease 3. Amyloidosis 4. Diabetic glomerulonephropathy 5. Focal segmental glomerulosclerosis 6. Membranoproliferative glomerulonephritis |
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What does is mean when a glomerulo disease ends in "itis"
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immune COMPLEX disease (Type III hypersensitivity)
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Define nephritic syndrome
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1. hematuria
2. RBC casts in urine 3. proteinuria < 3.5g/day (also azotemia, oliguria, and HTN) |
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Define nephrotic syndrome
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1. Proteinuria > 3.5g/day
2. Lipid casts/hyperlipidemia/"frothy" urine 3. edema |
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Findings and cause (if known) for Acute Poststreptococcal glomerulonephritis
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Sx: Kids, periorbital edema, resolves spontaneously
LM: "lumpy bumpy", sub-epithelial humps IF: granular Cause: after strep infection |
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Findings and cause (if known) for Rapidly Progressive glomerulonephritis
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Sx: Usually male, lung also involved
LM: crescent moon shape IF: linear (Goodpastures, Type II hypersensitivity is the most common cause) *this breaks goljan's "itis" rule Cause can also be Wegener's (c-ANCA) or Microscopic polyarteritis (p-ANCA) |
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Findings and cause (if known) for Diffuse Proliferative glomerulonephritis
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Sx: #1 death in SLE (could also present as nephrotic)
LM: "wire looping" IF: granular Cause: SLE |
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Findings and cause (if known) for Berger's Disease
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Sx: aka "IgA Glomerulopathy", follows Upper Resp. Infection!
LM: Immune complexes in mesangium |
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Findings and cause (if known) for Alport's Syndrome
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Sx: Nerve disorder, sight and hearing problems
LM: split basement membrane |
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Findings and cause (if known) for membranous glomerulonephritis
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Sx: #1 adult glomerulonephropathy (also SLE when it presents as nephrotic)
LM: spike and dome, thickend GBM IF: granular Cause: various DRUGS, infections, or SLE |
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Findings and cause (if known) for minimum change disease
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Sx: #1 kid nephrotic syndrome, presents after illness, tx with steroids
LM: normal IF: normal EM: fused podocytes Cause: various DRUGS, infections, or SLE |
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Findings and cause (if known) for amyloidosis
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Sx: Assc with mult myeloma, chronic conditions, TB, RA
LM: condo red stain, apple-green birefringence |
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Findings and cause (if known) for diabetic glomerulonephropathy
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Sx: diabetic sx's
LM: Kimmelstiel-Wilson "wire loop" lesions Cause: Non-enzymatic glycosylation of GBM causes increased GFR and mesangial damage |
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Findings and cause (if known) for focal segmental glomerulosclerosis
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Sx: HIV!!!
LM: segmental sclerosis and hyalinosis Cause: HIV...bad prognosis |
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Findings and cause (if known) for membranoproliferative glomerulonephritis
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Sx's: HBV assc!!! (could also be HCV), progresses to CRF
LM: Sub-endothelial immune complexes IF: Granular EM: "Tram-track appearence" |