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6 Cards in this Set
- Front
- Back
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Mechanism of Anaphylaxis |
Sensitising Dose and shocking Dose IgE produced against antigen attaches to surface of receptors of mast cell and basophil IgE bind by Fc end |
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Chemical mediators |
2 types Primary = histamine,seretonin,eosinophil,proteolytic enzymes Secondary = SRS(produced by leukocytes), prostaglandins and TXA2,PAF,cytokines such as IL3 to IL6 Other mediators = bradykinin and other kinins |
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Features of anaphylaxis |
Occur within few seconds to few minutes Cytropic IgE responsible Tissue or organ affected is called target tissue or shock organ |
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Types of anaphylaxis |
In vitro Cutaneous Passive cutaneous |
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Atopy |
Familial hypersensitivity which occur spontaneously in man Typified hay fever and asthma Antigens involved pollen, house dust and foods. |
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Features of Atopy |
Atopy runs in families Tendency to produce reagin antibody in large amount Contact leads to local allergy IgE mediated |
