Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
19 Cards in this Set
- Front
- Back
biotransformation
|
metabolism
|
|
blocker
|
antagonist
|
|
blood-brain barrier
|
selective mechanism that opposes the passage of most ions and large molecular compounds from the blood to the brain tissue
|
|
clearance
|
rate of disappearance of the drug molecules from circulation
|
|
distribution
|
the delivery of the drug into any and all body compartments it can penetrate
|
|
excretion
|
removal of a drug (or its metabolites) from the body
|
|
first-pass effect
|
drugs entering the body by the enteral route first go through the portal circulation to the liver before reaching the general circulation
|
|
half-life
|
the time needed for the plasma concentration of a drug to be reduced to 50%
|
|
intrinsic activity
|
a combination of affinity and efficacy
|
|
metabolism
|
conversion of the rug into another substance or substances
|
|
metabolites
|
end product of chemical change of one drug into another
|
|
P-450
|
enzyme system to metabolize drugs
|
|
placebo
|
inactive substance
|
|
prodrug
|
drug that requires conversion into its active form
|
|
pharmacotherapeutics
|
reason the drug is prescribed
|
|
steady state
|
administration rate of a drug equals its elimination rate
|
|
therapeutic index
|
relation of ED50 + LD50
|
|
primary site for metabolism
|
liver
|
|
affinity
|
the attraction of certain molecules to specific sites
|