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9 Cards in this Set
- Front
- Back
What cell types are peroxisomes found in ? What do peroxisomes look like. |
Peroxisomes are found in all cell types. They are bounded by a single membrane and have an amorphous matrix. Human peroxisomes do not have a crystal-like structure. Can be linked in a network or reticulum during formation Unlike mito, do not contain own DNA |
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what reaction takes place within? |
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What is the function of the peroxisomes and |
Both Peroxisomes and mito produce AcCoA
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What are the functions of Platelet Activating Factor? |
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Where do peroximsomes come from? |
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Peroxisomal Disorders are divided into two types. What characterizes those types? |
Single protein/enzyme deficiencies (structure abnormal) Organelle biogenesis deficiency |
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X-linked adrenoleukodystrophy (XALD) |
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Succesful Gene therapy for XALD |
HSCs from patient were transfected using lentivirus HIV vector which included ABC1 transporter DNA which incorporated into cells. HSCs were given back to the patient. |
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Zellweger Syndrome |
Involves defects in peroxisomal biogenesis. Extensive neuropathy and Hepatic and Renal dysfunction Accumulate VLCFA |