Pd 3

Front 1

Secondary Motor Symptoms

Most common symptom (Sullivan)

Back 1

fatigue

Front 2

Secondary Motor Symptoms - Characterized by a progressive increase in speed with a shortening of stride

Back 2

festinating gait

Front 3

Secondary Motor Symptoms festinating gait types:

Back 3

Anteropulsive(forward)=

Retropulsive(backward)

Front 4

Same with festinating but with decreased velocity

Back 4

shuffling gait

Front 5

Freezing of gait

Back 5

shuffling gait

Front 6

Sudden stops in movement

Back 6

freezing of gait/ freezing phenomenon

Front 7

Secondary to "off-stat"

Back 7

freezing of gait/ freezing phenomenon

Front 8

Non-motorsymptoms

• Sensory symptoms

Back 8

- Paresthesias

- Pain

- Olfactory dysfunction (anosmia)

Front 9

common with/ secondary to off state (levadopa- stops or not working)

Back 9

freezing of gait/ freezing phenomenon

Front 10

Non-motor symptoms:

pins & needles

Back 10

Paresthesias

Front 11

Non-motor symptoms:

secondary to rigidity

Back 11

Pain

Front 12

Non-motor symptoms:

CN involved in PD:

Back 12

CN 1,3,7,9

olfactory

oculomotor

facial

glossopharyngeal

Front 13

Non-motor symptoms:

impaired swallowing

Back 13

Dysphagia

Front 14

Non-motor symptoms:

May result to sialorrhea or excessive drooling

Back 14

Dysphagia

Front 15

Non-motor symptoms:

• Speech disorder

Back 15

Hypokinetic dysarthria

Front 16

Non-motor symptoms:

Characterized by decrease voice volume, monotone speech, distorted articulation and controlled speech rate

Back 16

Hypokinetic dysarthria

Front 17

Non-motor symptoms:

Cognitive dysfunction

Back 17

- Mild (impaired memory)

- Severe (psychosis)

Front 18

Non-motor symptoms of PD

Back 18

• Sensory symptoms

• Dysphagia

• Speech disorder

• Cognitive dysfunction

• Depression and anxiety

• Autonomic dysfunction

• Sleep disorder

Front 19

Non-motor symptoms:

Sleep.disorder

Back 19

Excessive day time somnolence (sleepiness)

Insomnia

REM (rapid eye mvmt) sleep behavior disorder

Front 20

Non-motor symptoms:

autoimmune disfunctions

Back 20

(+) lewy bodies in the ANS

seborrhea

GI d/o

urinary incontinence

erectile dysfunction

OH

Front 21

cytoplasmic incision bodies d/t neuronal degeneration

Back 21

(+) lewy bodies in the ANS

Front 22

proteins

Back 22

(+) lewy bodies in the ANS

Front 23

increase oil production/ secretion

Back 23

seborrhea

Front 24

MC GI d/o in PD pt?

Back 24

constipation

Front 25

Associated with cell loss in the caudate nucleus and putamen

Back 25

Huntington disease

Front 26

Huntington disease Cardinal features:

Back 26

Dementia

Depression

Chorea

Front 27

hallmark of Huntington disease

Back 27

chorea

Front 28

Onset:3rd or 4th decade of life (30-40)

Back 28

Huntington disease

Front 29

MC cause of death: pneumonia and cardiovascular disease

Back 29

Huntington disease

Front 30

Mutation of huntingtin

Back 30

Huntington disease

Front 31

Progressive disorder characterized by gait ataxia with diminished nuscle stretch reflexes joint, position sense, and vibratory sense

Back 31

Friedrich Ataxia

Front 32

MOI: Autosomal dominant (AD)

Back 32

Huntington disease

Front 33

AR autosomal recessive

Back 33

Friedrich Ataxia

Front 34

Onset: Teens

Back 34

Friedrich Ataxia

Front 35

Mutation in FRATAXIN

Back 35

Friedrich Ataxia

Front 36

Hereditary Spastic Paraparesis Aka:

Back 36

Familial Spastic Paraplegia Strumpell-Lorrain Syndrome

Front 37

Progressive bilateral lower limb spasticity and weakness

Back 37

Hereditary Spastic Paraparesis

Front 38

MOl: AD, AR, X-linked

Back 38

Hereditary Spastic Paraparesis

Front 39

32 HSP loci and 11 HSP

Back 39

Hereditary Spastic Paraparesis

Front 40

Abnormal contraction of the eyelid muscles

Back 40

Eyes (blepharospasm)

Front 41

Sustained contraction of agonist and antagonist muscle

Back 41

Dystonia

Front 42

Dystonia examples:

Back 42

Ex: Cervical dystonia (torticollis)

Eyes (blepharospasm)

Front 43

MC focal dystonia

Back 43

Cervical dystonia (torticollis)

Front 44

AD (idiopathic)

Back 44

Tourette syndrome

Front 45

a constellation of symptoms including tic disorders and comorbid neurobehavioral problems

Back 45

Tourette syndrome

Front 46

Involuntary, sudden, rapid, repetitive, non rhythmic,stereotyped movements or vocalizations

Back 46

Tics

Front 47

(+) Tics

Back 47

Tourette syndrome

Front 48

most serious complication of PD

Back 48

bronchopneumonia/ Pneumonia

Front 49

MC cause of death in PD

Back 49

bronchopneumonia/ Pneumonia

Front 50

purposeless uniformity repetitive voluntary contraction/movement

Back 50

stereotypsy

Front 51

common:

head nodding

head bang

Back 51

stereotypsy

Front 52

subject restlessness & compulsion to move about

Back 52

akathisia

Front 53

common in LE

(+) toe tapping

(+) leg shaking

Back 53

akathisia

Front 54

sudden brief, irregular contraction of a group of muscle that may occur at rest or with voluntary movement

Back 54

myoclonus

Front 55

example:

hiccups

asterexis

Back 55

myoclonus

Front 56

asynchronous ms. twitching

Back 56

asterexis

Front 57

rapid, jerky, irregular mvmt

Back 57

chorea

Front 58

slow & writhing mvmt

Back 58

athetosis

Front 59

slow & fluid motion

Back 59

athetosis

Front 60

worm-like mvmnt

Back 60

athetosis

Front 61

MC in proximal limb

Back 61

ballismus

Front 62

Autosomal dominant disorders

Back 62

huntington's disease

hereditary spastic paraparesis

Tourette syndrome