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3 Cards in this Set

  • Front
  • Back

Four Stages of Gout

Asymptomatic hyperuricemia-Puberty in men and menopause in women


Acute Arthritis-After several years. Acute pain. 50 %in first metatarsophalangeal joint.


Asymptomatic intercritical period- symptom free interval


Chronic tophaceous gout-Develops about 12 years after acute attack. Radiography show juxtaaeticular home and loss of joint space.

Uric acid is the end product of

Purine production

What are the two pathways of purine nucleotide production?

De Novo: Purine nucleotides are synthesized from nonpurine precursors


Salvage: Synthesized from free purine bases through diet or catabolism of purine nucleotides