Ob Gyn

Front 1

Estrogen

Back 1

Use: HYPOgonadism; HRT- premature ovarian failure, menopause, no ovaries

Effects: need for normal female reproduction, growth genitals and 2nd character, modifies protein levels, borne resorption, enhance coagulation; inc TG
dec LDL

ADR: X secretion of GnRH
premature closure of epiphyseal plates; short; inc. breast ca; heart; NV; tender breast; migrain; DVT; GB dz; inc. TG; HTN

Front 2

Progestin
- L Norgestrel

Back 2

Use: contraceptive; HRT; promote and maintain preg

Effects: endometrial change; maintains preg; stabalize endometrium; change CHO metabolism (NOT protein); stim fat deposition

ADR: dec GnRH suppression --> anovulation; HTN; dec. HDL; dec bone density; slow to resume ovulation

*progestin does NOT inhib ovulation

Front 3

Tamoxifen

Back 3

SERM
Use: breast cancer
effects: partial ANTagonist

Front 4

Raloxifen

Back 4

SERM
use: breast cancer + osteoporosis
effects: partial ANTagonist

Front 5

Clomiphene

Back 5

SERM
use: anovulatory women
effects: partial AGONIST;
induces ovulation, blocks ER in pituitary --> neg feedback --> inc. LH and FSH and GnRH --> stim ovulation

Front 6

Fulvestrant

Back 6

pure ER ANTagonist

use: breast cancer when tamoxifen doesnt work

Front 7

Danazol

Back 7

Weak partial AGonist of PROGESTERONE

use: endometriosis; fibrocystic ovary dz

effects: inhib p450 to stop gonadal steroid synth;

Front 8

Anastrozole

Back 8

Aromatase inhib

use: breast cancer

effects: nonsteroidal COMPETITIVE inhib of synthesis

Front 9

Examestane

Back 9

Aromatase inhib

use: breast cancer

effects: IRREVERSIBLE inhib of synthesis

Front 10

Mifepriston

Back 10

ANTI-progesterone

use: abortion

effects: ANTagonist of progesterone and glucocorticoid

ADR: NV, Diarrhea, cramping, bleed

Front 11

Oxytocin
-Pitocin
-Syntocinon

Back 11

Oxytocic Agent
-natural hormone 8 AA; made in hypo stored in pit
-inactivated by liver and kidney

use; drug of choice for INDUCTION of labor; labor problems; incomplete abortion; after full term delivery to stop uterine hem

ADR:
in high dose = abortion
waterin intoxication because is antidiuretic

Front 12

Ergot Alkaloids
- Ergonovine
-methylergonovine

Back 12

Oxytocic Agent
-found in breast milk
-excreted by kidney

Use: stim sm ctx.; enhance force and rate of ctx;
vasoconstricts
*only ergonovine stimulates cervical contraction
used in final stages only to shorten labor; helps stop postpartum blood loss; remove placenta

MAO: PARTIAL alpha adrenergic rec- agonist contracts, blocker stops
5HT, DA rec activity
inhib EDRF

ADR: HTN; seizure; chest pain from alpha activity; can't breathe; leg cramp

CONTRA: MI, CVA, TIA, HTN
long term = gangrene in baby

Front 13

Prostoglandins

Back 13

Oxytocic Agent

use: inc ctx
use with caution if viable fetus

ADR: NV, fever, retained placental fragments, excessive bleed, dec diastolic, HA
CONTA: DO NOT use with oxytocin
Asthma; cervicitis; vaginitis; change BP; anemia; jaundice; dm; epilepsy; PID; active renal, hepatic, CV problems

Front 14

Dinoprostone

Back 14

Oxytocic Agent
-PGE2 agent

use: stim ctx; induce abortion 12-20 weeks; cervical ripening;
better ctx stimulator at 2nd trimester than oxytocin

Front 15

Carboprostromethamine

Back 15

Oxytocic Agent
- PGF2a

use: stim ctx; induce abortion;
NO cervical ripening
better ctx stimulator at 2nd trimester than oxytocin

Front 16

Misoprostrol

Back 16

Oxytocic Agent
-PGE1

use: labor induction/ abortion
CERVICAL ripening

Front 17

Ethanol IV

Back 17

Tocolytic Agent

use: inhib oxytocin release; dec ctx;

not used anymore

Front 18

B2 adrenergic agonist

Back 18

Tocolytic Agent

use: stops PTL >20 weeks
arrests the PTL for 48-72 hrs

MAO: activates adenylate cyclase; inc. cAMP and kinase; dec. ca --> stop ctx

ADR: palpitation, tremor, nv, nervous, chest pain, SOB, ekg change, hyperglycemia, hypokalemia, hypotension, pulm edema, MI, mom dies

Front 19

Ritodrene

Back 19

Tocolytic agent
-B2 activity

use: CANNOT give repeat dose

MAO: 30 min affect

ADR: tachy, hypotension

Front 20

Terbutaline

Back 20

Use: asthma; REPEAT dose...should NOT be given for tocolysis

ADR: hyperglycemia

Front 21

Mg Sulfate

Back 21

Tocolytic Agent

Use: Preeclampsia;
preferred in Dm, heart prob, hyperthyroid

MAO: uncouples excitation contraction in heart cells; dec. ca; activates adenylate cyclase

ADR: lose pateller reflex, resp depression, resp paralysis, cardiac arrest, sweat, dry mouth, dizzy, palpitation, NV, nystagmus, flush, ha

Front 22

Indomethacin

Back 22

Tocolytic Adent
-NSAID

use: after baby born to close ductus arteriosus; prolong spont labor; stop PTL

MAO: dec. PG production; inc gestation length

ADR: premature closure of fetal ductus arteriosus, pulm hypotension; inc. hemorraghe

Front 23

Hydroyprogesterone

Back 23

Tocolytic

Use: good at 12-37 weeks

ADR: teratogenic

Front 24

Diazoxide

Back 24

Tocolytic
-antiHTN drug

MAO: activates K chan; relax xm; hyperpolarize cell membrane

Front 25

Atosiban

Back 25

Tocolytic

Use: under trial...stops ctx

MAO: Anti oxytocin - comp inhib

Front 26

Bromocriptine

Back 26

Tocolytic

use: to stop lactation

MAO: DA agonist - inhib release prolactin

Front 27

Mifepristone
-RU 486

Back 27

Tocolytic

Use: abortion- but can't use alone...must use with PG

MAO: anti progesterone

ADR: mom dies