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84 Cards in this Set
- Front
- Back
Acetylocholine ionotropic receptor agonists
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Nicotinic
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Acetylcholine metabotropic receptor agonists
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Muscarinic
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Acetylcholine Ionotropic/nicotinic receptor antagonists
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decamethonium (partial agonists)
succinylcholine (partial agonists) |
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Acetylcholine metabotropic/muscarinic receptor antagonists
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Atropine
pirenzepine AF-DX 116 |
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Glutamate ionotropic receptor subcategories
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NMDA
AMPA Kainate |
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Glutamate receptor agonists
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NMDA
AMPA Kainate |
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Glutamate receptor antagonist
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APV
CNQX |
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GABA receptor agonists
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GABA
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GABA receptor antagonists
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picrotoxin
Bicuculline |
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Barbituate/steroid effect of GABA receptor
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increases conductance of chlorine even without GABA bound
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Benzodiazapine
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Increases effect of GABA.
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Open channel blocker
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PCP - Glutamate Channel
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Glycine Agonist
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Glycine
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glycine agonist
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glycine
Ethanol |
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Nucleotide and cyclic nucleotides agonist
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adenosine
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Nucleotide antagonist
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caffeine
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Caffeine prevents__________ of _______ ________ producing the same effect as
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inhibition of inhibitory receptors
strychnine |
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Glycine antagonist
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strychnine
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Glycine precursor
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serine
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Acetylcholine precursor
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acetyl CoA and choline
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Glutamate precursor
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glutamine
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GABA precursor is
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bicuculine
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Nucleotide/cyclic nucleotide precursor is
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ATP
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Catecholamine neurotransmitters
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Dopamine
Epinephrine Norepinephrine Serotonin |
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Dopmine agonist
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Dopamine
Cocaine Morphine MPTP |
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Dopamine antagonist
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Haldol
Thorazine |
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Haldol and Thorazine are
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sedatives
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Dopamine precursor is
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tyrosine
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Epinephrine agonist is
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ephedrine
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Ephedrine is
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source of methamphetamines which are stimulants
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Epinephrine antagonists are
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B blockers - block the B form of receptors in heart
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Epinephrine precursor is
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tyrosine to dopamine
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Norepinephrine agonist
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Welbutrin
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Norepinephrine antagonist for brain
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Pb and Hg
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Norepinephrine precursor is
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tyrosine to dopamine to epinephrine to norepinephrine
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Serotonin is a
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biogenic amine
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Loss of serotonin leads to
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depression
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Serotonin agonist is
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Buspar - Prozac
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Serotonin antagonist is _______ which blocks
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Phen-Phen
reward sensation of eating food |
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Neuropeptides include
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endorphins
anandamides |
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Endorphin means
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endogenous morphine
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We found the ________ _______ before we found ________.
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endorphin receptor
endorphin |
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Endorphin agonist is
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opium
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Anandamides bind
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endogenous cannabinoid receptor
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Adenosine receptors are bound antagonistically by
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xanthines
caffeine theophylline |
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Theophylline is the precursor for
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theobromine in chocolate
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Theobromine binds ___________ along with ________
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love receptors
caffeine |
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Dopamine activates __________ and acts as a ___________
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motor control
stimulant |
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Epinephrine will bind
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specific adenergic receptors
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amphetamines will bind
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all catecholamine or serotonine receptors
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Methamphetamine binds
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all seratonergic, dopanergic, peinergic, and norepinergic receptors
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Benzedrine binds _________
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adrenergic beta epinergic receptors
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Amphetamine not only binds ________ and _______. But also binds
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epinergic and dopanergic receptors,
presynaptic reuptake receptors |
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Amphetamine preferentially binds
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dopamine receptors
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Methamphetamine binds
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dopanergic, epinergic, norepinergic and seronergic receptors
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Cocaine reverses flow of
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presynaptic receptor
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Pharmaceutical grade amphetamines bind
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specific receptors because of manufacturing control of chiral carbons
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Street drugs bind
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all receptors because of various forms of chiral carbons
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Cocaine binds ________ and ________
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epinephrine, dopamine (preferentially) and serotenergic reuptake receptors causing uncontrolled dopamine release
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Amphetamines
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activate adrenergic receptors in the PNS
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Adderall chemical name
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dextroamphetamine
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Benzodiazapines for _________ receptors
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Xanax
Rohypnol Valium GABA |
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Barbituates for _________ receptors
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Seconal
Nembutal |
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COMT:
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Catechol-O-Methyl Transferase
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MAO
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Mono Amine Oxidases
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MAO's have _____ subtypes based on ______ _______ they affect
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2
Neurotransmitter MAO-A and MAO-B |
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First generation antidepressants
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Phenelzine (Nardil)
Isocarboxazide (Marplan) |
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Nardil
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anti-depressant
anti-anxiety anti-phobic |
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marplan
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anti-depressant but also affects GABA
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Second Generation antidepressants
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Tofranil
Norpramin |
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Third Generation Antidepressants
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Prozac
Zoloft Cypramil Paxil |
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The serotonin binding site includes
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an ionic site, and polar ring site, and a polar site
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COMT can break down ________ without reducing the amount of _________
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dopamine
norepinephrine |
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First generation anti-depressants were _____ ____ and affected the
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MAO inhibitors
Norepinephrine pathways |
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First generation anti-depressants also affected the
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GABA reversing effect - inhibiting pathways.
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Second generation antidepressants increased ______, and decreased
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release of norepinephrine,
reuptake of norepinephrine |
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Third generation anti-depressants affect
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Serotonin reputake receptors
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Prozac dosage has to be
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increased over time because of new receptors being produced
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Hallucinogens bind
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serotonin receptors better than serotonin
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When we first wake our serotonin levels are at their
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lowest
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Serotonin is also important in
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wakefullness
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These compounds bridge the gap between consciousness and unconsiousness
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Serotonin, Mescaline, Lysergic Acid, and Psilocybin
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THC causes
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retrograde inhibition of Ca++ pathway
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Endocannabinoids affect the
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pain pathway
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