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22 Cards in this Set
- Front
- Back
Bethanechol
|
muscarinic selective agonist
no AChE hydrolysis |
|
Muscarine
|
from mushrooms
muscarinic selective agonist |
|
Pilocarpine
|
-muscarinic selective agonist
-glaucoma treatment (produces miosis) |
|
Arecoline
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from Betel nut
muscarinic=nicotinic agonist |
|
Effects of muscarinic agonists on heart
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normal to high doeses produce decreased HR via direct action on the heart
there is little effect on contractility |
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Effects of muscarinic agonists on blood vessels
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muscarinic receptor stimulation cuases synthesis & release of NO leading to vasodilation
|
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Too much of muscarinic agonist would produce parasympathomimetic or parasympatholytic effects?
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parasympathomimetic effects
|
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Edrophonium
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-AChE inhibitor
-used to diagnose myasthenia gravis -short acting |
|
Donepezil
|
-long lasting AChE inhibitor
-used to treat Alzheimer's |
|
Physostigmine
|
-AChE inhibitor
-tertiary amine w/ CNS activity -glaucoma treatment |
|
Neostigmine
Pyridostigmine |
-AChE inhibitor
-no CNS activity -myasthenia gravis treatment |
|
Carbaryl
|
-AChE inhibitor
-carbamate -selectively toxic to insects |
|
Malathion
Parathion |
-AChE inhibitor
-thiophosphates |
|
Atropine
|
-muscarinic blocker
-reveres muscarinic effects of AChE toxicity |
|
Pralidoxime
|
-AChE reactivator
-has higher affinity for organophosphate AChE inhibitor compared to AChE -it pulls the organophosphate off AChE protein |
|
Ipratropium
|
-muscarinic antagonist
-COPD treatment |
|
Sarin
|
-nerve gas
-AChE inhibitor -high degree of dermal & pulmonary absorption |
|
This "---stigmine" has CNS activity.
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Physostigmine
|
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Used to diagnose myasthenia gravis
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Edrophonium
|
|
Muscarinic agonist used to treat glaucoma
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Pilocarpine
|
|
Belladonna alkaloids
|
Atropine
Hyoscyamine Scopolamine |
|
This belladonna alkaloid has marked CNS effects.
|
Scopolamine
|