Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
34 Cards in this Set
- Front
- Back
- 3rd side (hint)
Heterotropic presynaptic inhibition |
Symp and parasymp in the heart |
|
|
Pre synaptic inhibition example |
Noradren. And cholinergic |
|
|
Hemicholium |
Choline carrier antagonist |
|
|
Non depolarsing blocking agents |
Tubocurarine |
|
|
Botulinum |
Presynaptic toxin |
|
|
Vesimicol |
Ach carrier antagonist |
|
|
Post synaptic synergism |
|
Npy helps sympa NA ATP in vessels Ach Sp in enteric Ach vip to blood vessels |
|
Depolarizing blocking agent |
Suxamethonium |
|
|
4 sites of Ach receptors |
|
|
|
Blood pressure Ach and Muscarinic receptors |
Ach > 👆 NO vasodilation Atropine blocks M achR At extreme doses of ach... N achR symp. Ganglions activated vasoconstriction and hypertension |
|
|
Cardiac effects of M receptors agonists |
M2 |
|
|
Pulmonary effect M3 agonists |
|
|
|
Vascular effects of M3 agonists |
|
|
|
Ocular effects of M agonists |
M3 |
|
|
Amphetamine mechanisim |
|
Extravesicular secretion of NA |
|
GI effects M1 and M3 agonists |
|
|
|
Urogenital effects M3 |
|
|
|
Cholinomimetics |
Bethnichol M3 for bladder and gut hypotonia Pilocarpine for glaucoma by inducing relaxation of the lens by contracting the zonule fibers also acute angle glaucoma by miosis Carbacholine miosis as well as acting as nicotinic agonist Methacholine test of asthma (induced bronchoconstriction) Verriclin nicotinic... |
|
|
Bathanechol |
M specific Bladder and GI hypotonia(with no obstruction) |
|
|
Cevimeline |
M3 specific Sjgron treatment |
|
|
Pilocarpine |
M specific Glaucoma improved drainage |
|
|
Effects of M3 agonists on Nasopharyngeal , tear and sweat gland(sympathetic). |
|
|
|
Edrophonium use |
Short 2 min achE inhibitor Tense line test > diagnose myasthenia gravis from cholinergic strom |
|
|
Types of achE |
|
|
|
AchE inhibitors intermediate action BBB penetration and use |
Carbamoyl esters: 6 hours Physostigmine tertiary Neostigmine Quat Pyridostigmine Demacarium Quat Used for Glaucoma, bladder and intestinal atonia myasthenia(with atropine) Tubacuarine reverse Atropine intoxication Alzheimer's(damage of chole.neurons) |
|
|
Irreversible AchE Inhibitors effects |
|
|
|
M1 M2 M3 |
Gq. Gi Gq Cns. Heart. Smooth m. Enteric. Cardiac - glands blad Gastric sec. Eye. Vessels Ip3DAG. 👇 cAMP. Gi |
|
|
Neostigmine use |
Quat AchE inhibitor Reverse nicotinicR non depolarising Inhibitors curare But no succinylcholine (dep) |
|
|
Prydostigmine use |
Quat Treatment of myasthenia gravis |
|
|
Drugs used for alzehimer treatment |
Tertiary AchE inhibitors Specifically Galantamine Rivastigmine And Donpezil |
|
|
Irreversible AChE inhibitors |
Parathion malathion Eyedrop=ecothiopate Treated with pralidoxim N and M peripheral and ATROPINE central M |
|
|
AchE inhibitors short acting and use |
Edrophonium 10 min Used to diagnose myasthenia gravis |
|
|
Use of Physostigmine |
Tertiary Atropine intoxication |
|
|
Signs of AchE intox |
M Tearing sweating incontinence diarrhea and urination Cns damage tremors and ataxia and coma miosis lacrimation bronchoconstriction bradycardia DUMBBELLS
N Paralysis and weakness
|
|