What is the mechanism of action of oxytocin?

By direct action on myofibrils, it causes phasic contraction of the uterine smooth muscle characteristic of normal delivery. It also promotes milk "letdown" in nursing mothers. Effective in inducing labor and uterine contractions following delivery, thereby controlling postpartum hemorrhage.

What are the listed contraindications for oxytocin?

Hypersensitivity and prior to delivery of the fetus. Administration prior to delivery may cause fetal hypoxia, asphyxia, and dysrhythmias

What are the listed precautions for oxytocin?

Can cause over stimulation of the uterus resulting in uterine rupture thus vitals and uterine tone should be monitored

What are the listed side effects for oxytocin?

- Hypotension - Anxiety - N/V - Dysrhythmias - HTN - Seizures - Dyspnea - Coma - Intracranial bleeding

What are the listed interactions for oxytocin?

Can cause hypertension when used in conjunction with vasoconstrictors

What is the dosage and route of oxytocin?

Bolus: 3-10 units IM Infusion: 10-20 units in 1000mL NS via 60 gtts/mL set and titrate to effect

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NEEMSI Paramedic Pharmacology - Oxytocin

Neemsi Paramedic Pharmacology - Oxytocin

by Andrew Jeffery, Nov. 2011

Subjects: ems emt neemsi paramedic pharmacology

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What is the best-known trade name for oxytocin?	Pitocin	Oxytocin is also sold as Syntocinon and is available as a generic
What is the functional class of oxytocin?	Hormone	Oxytocin is released into the blood from the posterior lobe (neurohypophysis) of the pituitary gland.
What is the mechanism of action of oxytocin?	By direct action on myofibrils, it causes phasic contraction of the uterine smooth muscle characteristic of normal delivery. It also promotes milk "letdown" in nursing mothers. Effective in inducing labor and uterine contractions following delivery, thereby controlling postpartum hemorrhage.	Many studies have shown that oxytocin is also involved in human bonding, increases in trust and generosity, and decreases in fear.
What are the listed indications for oxytocin?	Postpartum hemorrhage	The Center of Cognitive Neuroscience in Lyon, France concluded that oxytocin may help reduce the negative symptoms of autism.
What are the listed contraindications for oxytocin?	Hypersensitivity and prior to delivery of the fetus. Administration prior to delivery may cause fetal hypoxia, asphyxia, and dysrhythmias	Oxytocin is used prior to delivery in the hospital setting.
What are the listed precautions for oxytocin?	Can cause over stimulation of the uterus resulting in uterine rupture thus vitals and uterine tone should be monitored	Oxytocin has been shown to have an intrinsic antidiuretic effect, acting to increase water reabsorption from the glomerular filtrate. Consideration should, therefore, be given to the possibility of water intoxication, particularly when oxytocin is administered continuously by infusion and the patient is receiving fluids by mouth.
What are the listed side effects for oxytocin?	- Hypotension - Anxiety - N/V - Dysrhythmias - HTN - Seizures - Dyspnea - Coma - Intracranial bleeding	Fatal afibrinogenemia has also been reported
What are the listed interactions for oxytocin?	Can cause hypertension when used in conjunction with vasoconstrictors	Use with cyclopropane anesthesia can produce hypotension and cardiac dysrhythmias
What is the dosage and route of oxytocin?	Bolus: 3-10 units IM Infusion: 10-20 units in 1000mL NS via 60 gtts/mL set and titrate to effect	Oxytocin is typically packaged in a 1ml (10 unit) vial.