Naplex Review (Id)

Front 1

Gm + stain?

Back 1

purple/bluish

Front 2

Gm - stain?

Back 2

pink/redish

Front 3

MIC definition?

Back 3

lowest drug concentration that prevents microbial growth in 24 h

Front 4

Minimum bactericidal concentration?

Back 4

lowest drug concentration that reduces bacterial density by 99.9% in 24h

Front 5

Facts to consider when selecting a drug regimen?

Back 5

Site of infection
Severity of disease
Patient characteristics (age, renal function, liver function, allergies, pregnancy, etc)
Spectrum of drug activity
Etiology of infection

Front 6

Monitoring for Abx therapy effectiveness

Back 6

WBC, procal, esr, crp, fever, radiological findings, pain/inflammation, reduction in s/sx

Front 7

MOA of aminoglycosides?

Back 7

inhibit protein synthesis by binding the 30s subunit of the ribosome

Front 8

AG are concentration dependent or time dependent killing?

Back 8

dependent; have post antibiotic effect

Front 9

What is post antibiotic effect?

Back 9

continued suppression of growth when concentration is below MIC

Front 10

AGs blackbox warning?

Back 10

neurotoxicity (vertigo, ataxia) and nephrotoxicity

Front 11

AGs spectrum?

Back 11

mainly against gram - bacteria but can be used in synergy against staph and enterococcus

Front 12

Which AG has the broadest spectrum?

Back 12

amikacin

Front 13

How are AGs dosed?

Back 13

IBW unless ABW is less; use adj is ABW is >30% of IBW

Front 14

AG monitoring?

Back 14

peak/trough if conventional dosing, trough if extended interval. collect peak serum level (PSL) exactly 1 hr after start of infusion of 3rd dose (MDD)

Front 15

AG pregnancy category?

Back 15

D

Front 16

Neomycin dosing?

Back 16

prophylaxis GI surgery = 1g po tid w/ erythro
hepatic coma= 4-12g per day po
(sanford)

Front 17

Gentamicin/tobramycin multiple daily dosing/conventional dosing?

Back 17

2mg per kg load then 1.7mg per kg q8h
Peak 4-10mcg/ml and trough 1-2mcg/ml

Front 18

Gentamicin/tobramycin once daily dosing?

Back 18

5.1mg per kg q24h (7mg/kg if critically ill)
peak - 16-24mcg/ml & trough <1mcg/ml

Front 19

Amikacin multiple daily dosing?

Back 19

7.5mg per kg q12
peak 15-30mcg/ml & trough 5-10mcg/ml

Front 20

Amikacin once daily dosing?

Back 20

15mg/kg q 24h
peak 56-64mcg/ml & trough <1mcg/ml

Front 21

MOA of PCN?

Back 21

beta-lactams inhibit bacterial cell wall synthesis by binding to penicillin binding proteins (PBPs) which prevents the final transpepidation step of peptidoglycan synthesis in bacterial cell walls

Front 22

PCN concentration dependent or time dependent killing?

Back 22

time dependent

Front 23

AG bacteriostatic or bactericidal?

Back 23

bactericidal

Front 24

PCN bacteriostatic or bacteriocidal?

Back 24

bacteriocidal