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13 Cards in this Set

  • Front
  • Back

Whipple's disease Vs tropical sprue

Small intestine bacterial overgrowth

Cowdens syndrome

PTEN defect


GI hamartomatous polyps


Oral mucosal papillomas


Palmoplantar keratoses


Trichilemmomas


Thyroid dysfunction


Higher risk of breast and thyroid Ca


Gluten containing food

Wheat


Rye


Barley


Oat

Coeliac genetics

HLA DQ2


HLA B8

Pigmented macrophage in bowel wall

Melanosis coli


Laxative abuse eg senna

PBC Vs PSC

Hereditary defects in bilirubin metabolism

Unconjugated


- Gilbert's


- Crigler-Najjar type 1 and 2


(All above are caused by UDP glucuronosyltransferase 1A ie UGT1A deficiency)



Conjugated


- Rotor: organic anion transporting polypeptide (OATP)


- Dubin Johnson: multidrug resistant protein 2 (MRP2)/cMOAT

Chronic watery diarrhoea

Think bile acid malabsorption


SeHCAT test: two nuclear scans 7 days apart, abnormal if retention less than 10-15%



Low fat diet


Bile acid binders eg colestyramine

Enhanced liver fibrosis (ELF) blood test

Hyaluronic acid


Procollagen III


TIMP1

Micro Vs macronodular cirrhosis

Micronodular: Alcoholic liver


Macro: Chronic hepatitis

CEA Vs Ca19.9

CEA: colorectal CA


Ca19.9: pancreatic ca

Haematochromatosis