Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
46 Cards in this Set
- Front
- Back
Which DNA viruses are double stranded?
|
All DNA viruses except for Parvoviridae - Mnemonic: All are dsDNA like ours, except "Part-of-a-virus" which is ss.
|
|
Which DNA viruses are single stranded?
|
Parvoviridae
|
|
Which DNA viruses have linear genomes?
|
All except papova virus and hepadna which are circular
|
|
Which DNA viruses have circular genomes?
|
papova virus and hepadna which are circular
|
|
Which DNA viruses have infectious naked nucleic acids?
|
Most dsDNA Herpes, Adeno, Papov (except poxvirus and HBV)
|
|
Which DNA viruses have non-infectious naked nucleic acids?
|
poxvirus and HBV
|
|
Which enveloped viruses acquire their envelopes from the plasma membrane?
|
All except herpesviruses (nuclear membrane)
|
|
Which enveloped viruses acquire their envelopes from the nuclear membrane?
|
Only herpesviruses
|
|
Where do DNA viruses replicate?
|
In the nucleus (except pox)
|
|
DNA virus families
|
Mnemonic: DNA viruses are HHAPPPy - 1. Hepadna 2. Herpesviruses 3. Adenovirus 4. Parvovirus 5. Papovavirus 6. Poxvirus
|
|
Which DNA viruses are icosahedral?
|
All except pox (complex)
|
|
Which DNA viruses replicate in the nucleus?
|
All except pox (carries own DNA-dependent RNA polymerases)
|
|
Which DNA viruses are naked (no envelope)?
|
Mnem: Get naked for your PAP - 1. Parvo 2. Adeno 3. Papova
|
|
Which DNA viruses are enveloped?
|
HPH: 1. Hepadna 2. Pox 3. Herpes
|
|
Medical importance of HSV-1
|
1. Oral (and some genital) lesions (Gingivostomatitis) 2. Keratoconjunctivitis 3. Temporal lobe encephalitis
|
|
Medical importance of HSV-2
|
Genital (and some oral) lesions
|
|
Medical importance of VZV
|
1. Chickenpox 2. Shingles 3. Encephalitis 4. Pneumonia
|
|
Medical importance of EBV
|
1. Mononucleosis 2. Burkitt's lymphoma
|
|
Medical importance of CMV
|
1. Infection in immunosuppressed (especially transplant) 2. Congenital defects 3. Mononucleosis (negativie Monospot) 4. Pneumonia
|
|
Medical importance of HHV-6
|
Roseola (exanthem subitum): 1. High fever lasting 3 to 5 days which resolves and is followed by rash 2. Rash: mostly on trunk, lasting a day or two
|
|
Medical importance of HHV-8
|
Kaposi's sarcoma-associated herpesvirus
|
|
List of important Herpesviruses
|
1. HSV 1
2. HSV 2 3. VZV 4. EBV 5. CMV 6. HHV 6 7. HHV 8 |
|
Medical importance of Adenovirus
|
1. Febrile pharyngitis (sore throat) 2. Pneumonia 3. Conjunctivitis (pink eye)
|
|
Medical importance of Parvovirus
|
B19 virus causes: 1. Aplastic crises in sickle cell disease 2. "slapped cheeks" rash---erythema infectiosum (fifth disease) 3. Hydrops fetalis
|
|
List of Papova viruses
|
1. Papilloma 2. Polyoma (human BK and JC) 3. Simian Vacuolating virus (does not affect humans)
|
|
Medical importance of Papilloma virus
|
causes warts and cervical cancer, including CIN (cervical intraepithelial neoplasia)
|
|
Medical importance of JC virus
|
Progressive multifocal leukoencephalopathy in HIV
|
|
List of Pox viruses
|
1. Smallpox 2. Vaccinia (cowpox "milkmaid's blisters") 3. Molluscum contagiosum
|
|
How is HSV-1 transmitted?
|
Respiratory secretions and saliva
|
|
How is HSV-2 transmitted?
|
Sexual contact and perinatally
|
|
How is VZV transmitted?
|
Respiratory secretions
|
|
How is EBV transmitted?
|
Respiratory secretions, saliva
|
|
How is CMV transmitted?
|
1. Congenital 2. Transfusion 3. Sexual contact 4. Saliva 5. Urine 6. Transplant
|
|
How is HHV-8 transmitted?
|
Sexual contact
|
|
Treatment for CMV
|
Ganciclovir or Foscarnet
|
|
What kind of cell does Epstein Barr virus infect?
|
B cells
|
|
How does mononucleosis present?
|
1. Fever 2. Hepatosplenomegaly 3. Pharyngitis 4. Lymphadenopathy (especially posterior auricular nodes)
|
|
Peak incidence of mononucleosis
|
15-20 years old (peak kissing years)
|
|
Laboratory diagnosis of mononucleosis
|
1. Monospot test: Heterophil antibodies detected by agglutination of sheep RBCs. In EBV, positive. In CMV, negative. 2. Abnormal circulating CD8 cells.
|
|
Tzanck test
|
Smear of opened skin vesicle to detect multinucleated giant cells. Used to assay for HSV-1, HSV-2, VZV - Mnem: Tzanck heavens I do not have herpes. (helps if you do it in an eastern european accent)
|
|
DNA, DS, circular, enveloped virus?
|
Hepadnavirus
|
|
DNA, DS, linear, enveloped virus?
|
Herpesviruses and Pox (largest DNA virus)
|
|
DNA, DS, linear, nonenveloped virus?
|
Adenovirus
|
|
DNA, SS, -linear, nonenveloped virus?
|
Parvovirus
|
|
DNA, DS, circular, nonenveloped virus?
|
Papovavirus
|
|
DNA, DS, -linear, enveloped virus?
|
Poxvirus
|