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8 Cards in this Set
- Front
- Back
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What are the different strategies for rational drug design? |
• Vary alkyl and aryl substituents• Chain extension and contraction• Ring expansion, contraction and variation• Isosteric and bioisosteric replacements• Simplification• Rigidification |
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Acid Dissociation Constant Ka and pKa |
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What does a large Ka mean? |
A strong acid |
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What does a small Ka mean? |
A weak acid |
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What does a small pKa value mean? |
Strong acid |
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What does a large pKa value mean? |
Weak acid |
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What is the Henderson-Hasselbalch equation in terms of HA? |
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What is the Henderson-Hasselbalch equation in terms of HB+? |
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