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19 Cards in this Set
- Front
- Back
Drugs that inhibit folate manufacture of folate utilization?
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ANTI-FOLATES
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Drug used as part of the TX for toxolasmosis and alt. agent for prophylaxis of pneumocystis and toxoplasma?
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Pyrimethamine
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One of the DOC for TX and prophylaxis of pneumocystis?
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Trimethoprim
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DOC for the empiric therapy of UTIs in the outpatient population?
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Trimethoprim and Sulfamethoxazole
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Sulfa antibiotics (3)
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sulfadiazine
sulfisoxazole sulfamethoxazole |
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Those drugs that inhibit purine and pyrimidine synthesis indirectly by inhibiting folate manufacture cause what type of anemia?
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Type of macrocytic anemia known as megaloblastic anemia
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6-mercaptopurine is used in the treatment of which leukemia?
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ALL ( acute lymphocytic leukemia )
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6-mercaptopurine is converted to thio-IMP with which enzyme?
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HGPRT
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Drug that acts as a pyrimidine antagonist and used especially for non-lymphocytic leukemia?
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Cytarabine
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This inhibits thymidine synthesis?
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Fluorouracil (5-FU)
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Drugs discovered to be cytotoxic to human cells and therefore useful in the TX of CA?
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antibiotic cytotoxins
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At higher doses this drug inhibits DNA synthesis and at low doses it interferes with transcription?
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Actinomycin D (dactinomycin)
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This drug created radical oxygen species and decreases IP3 coupled transport processed?
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Doxorubicin (adriamycin)
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Cardiotoxic drug that can cause a cardiomyopathy resulting in heart failure?
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Doxorubicin
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This drug is nephrotoxic, hepatotoxic, toxic to skin, and has the ability to cause fibrosis of the lung?
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Bleomycin
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List the 4 Fluoroquinolones
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ciprofloxacin, levofloxacin, moxifloxacin, and gemifloxacin
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MOA of fluoroquinolones
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inhbit bacterial DNA gyrase
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These antibiotics are not approved in children <16 yo d/t risk of joint cartilage and caution must be taken in those >60 yo d/t increased risk for tendinopathy?
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Fluoroquinolones
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Fluoroquinolones have excellent action against Gram negative or Gram positive bacteria?
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BOTH
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