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26 Cards in this Set
- Front
- Back
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Approximately how many complement plasma proteins are there?
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30
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How many complement systems are there?
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4
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Name the complement systems
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classical
lectin alternative terminal |
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Which 3 complement systems share a common end point?
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classical
lectin alternative |
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What are the 4 biological consequences of complement activation.
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Cytolysis
Generation of bioactive substances Removal of particulate antigen or immune complexes Interaction with other inflame pathways. |
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Describe complement in 4 words.
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Self assembling enzymatic cascade.
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What do the classical lectin and alternative pathways lead to?
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Terminal pathways.
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In 3 words describe what the terminal pathways does.
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Cytolysis by MAC
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What do C3a and c5a act as?
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Anaphylatoxins and chemoattractants
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In as few words as possible describe the prices of opsonisation.
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Coating antigen in IgG and C3b = enhanced phagocytosis by interacting with FcR and C3bR on surface of phagoyctic cells.
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What is immune adherence?
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Helps remove particulate antigens from bloodstream.
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How was the classical pathway named?
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First to be discovered.
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How is the classical pathway triggered?
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Binding of C1 to a particulate antigen
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What will C1 bind to?
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Directly to cell wall lipoteichoic acid if g+ve
OR to c-reactive protein then bound to bacterial polysacharide most commonly immune complex of antigen/antibody |
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What sub units is C1 comprised of?
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C1q C1r C1s
QRS |
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What sequence are the c1 sub units activated?
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QRS
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Which C1 sub unit acts on C4 first?
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S
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What does C1s split C4 into?
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C4a and C4b
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Which sub unit of C4 then bind to the antigen surface?
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C4b
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Which C4b binds C2
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C4b
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What cleaves C2?
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C1s
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What is C2 cleaved to?
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sub units C2a and C2b
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After being cleaved by C1s, which sub unit remains associated with C4b?
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C2b
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Name sub units of C3 convertase
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C4bC2b
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What does C4bC2b do?
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Cleaves C3 into C3a and C3b
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Where does C3b deposit?
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Adjacent to C3 convertase to form C4bC2bC3b
C5 convertase. |
