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16 Cards in this Set
- Front
- Back
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How many domains does light chains have |
2 how many do |
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How many domains does heavy chains have |
4/5 |
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Carbohydrates are found on antibodies in a small amount what are they linked to |
N- or O- linked |
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Addition of carbohydrates affects what |
Solubility Secretion Catabolic rate |
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Hyper variable regions are called what |
Complementary determining regions CDR's |
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Regions between CDR's are called what |
Framework regions |
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The CDR's that make up the antibody combining site constitute what |
The paratope |
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The paradise is complimentary to the antigen combining site known as |
The epitope |
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Heavy chains contain |
Variable - diversity - joining - constant |
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Light chains contain |
Variable - joining - constant |
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What s the VDJ recombinase |
The process by which T cells and B cells randomly assemble different gene deferments known as variable diversity and joining genes in order to generate unique antigen receptors that can collectively recognise many different types of molecules |
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The V(D)J lymphoid specifics are |
RAG-1 and RAG-2 which are essential components expressed in developing lymphocytes only when recombination occurs |
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CDR1 is |
Somatic hypermutation |
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CDR2 is |
Somatic hypermutation |
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CDR3 is |
Somatic hypermutation |
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Small changes in amino acid composition of CDR's is associated with |
Antibody switching I.e from IgM to IgG to IgA primarily in the heavy chain |
