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30 Cards in this Set

  • Front
  • Back
Oxytocin is very similar to what hormone?
ADH
Oxytocin is secreted from what?
posterior pit
Required for the release (NOT synthesis) of milk
Oxytocin
Release of oxytocin is inhibited by what?
ETOH
Drug of choice for labor induction
oxytocin
Used to for stimulation of uterine motility postpartum to reduce bleeding
Oxytocin
MOA of Oxytocin
G protein coupled receptor-->+ PLC-->IP3-->Ca mobilization--> contraction
MOA of Atosiban
Oxytocin receptor ANTagonist (Delays labor)
releases arachidonic acids form phopholipids (membranes)
Phospholipase A2
MOA of PG?
Membrane --> AA --> PGH2 --> PGE2
What converts AA to PGH2?
COX
Blocks the conversion of AA to PGE2
NSAIDS that block COX
What does PGE2 do?
contracts the uterus and produces hyperalgesia
What does Indomethacin do to oxytocin induced uterine contractions?
Reduces them
Dinoprostone is PG what?
PGE2 (vaginal suppository)
TU of Dinoprostone?
Ripen the cervix (PGE2)
PG of Carboprost?
PGF2alpha (IM)
Name some SE of PG?
hyperalgesia, inflammation, fever, diarrhea
TU of Ergots?
Smooth muscle stimulating properties
Ergot that contracts the uterus
Ergonovine
Ergo that contracts BV?
Ergotamine
MOA or Ergonovine?
activates alpha, dopaminergic and 5 HT2 receptors
Used to tx migraine headaches
Ergotamine (Contracts BV)
Beta2 Agonists do what to labor?
delay
Mg Sulfate do what to labor?
delay it
MOA of Beta 2 agonists (Terbutaline and Ritodrine)
+ adenylate cyclase and raise cAMP levels
MOA of Mg Sulfate
competes with Ca to relax smooth muscle
Prevents seizures associated with eclampsia
Mg Sulfate
MOA Indomethacin
NSAID, blocks PG formation
MOA of Nifedipine
Ca channel antagonist (Tocolytic)