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18 Cards in this Set
- Front
- Back
Describe the mesangial cells
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derived from smooth muscle cells
produce mesangial matrix "intercapillary cells" possess contractile and phagocytic properties can proliferate |
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Describe the endothelial cells of the glomerulus
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Lines the capillaries themselves
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Describe the epithelial cell of the glomerulus
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AKA Podocyte, lies within Bowman's space, cover the capillaries
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What can happen with podocyte foot process effacement?
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Lipoid nephrosis; responds to steroids
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What can happen with podocyte hypertrophy?
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Focal segment glomerular sclerosis; edema all over body; do not respond to steroids long term
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What can happen with podocyte crescents?
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Wegener's granulomatosis
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What nephron feature is associated with diabetes mellitus?
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Thick basement membrane, Increased matrix
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What glomerular feature is associated with Alport's syndrome?
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Thin basement membrane
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What nephron feature is associated with arterial narrowing?
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Wrinkled/collapsed basement membrane/capillary wall
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What basement membrane patter is associated with membranous nephropathy?
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Subepithelial deposits
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What pattern of injury is associated with Lupus nephritis?
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Subendothelial deposits
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What pattern of injury is associated with Lupus nephritis?
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Subendothelial deposits
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What mesangial cell pattern is associated with Post infectious GN?
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Increased mesangial cells
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What pattern of injury is associated with Berger's disease (IgAN)?
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Increased mesangial matrix and cells
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What pattern of injury is associated with mesangiocapillary GN?
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Interposition of mesangial cells
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What are the LM features of the proximal convoluted tubule?
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Location: cortex, most numerous tubule segment
Cytoplasm: eosinophilic, granular (numerous mitochondria) Lumenal Surface: brush (microvilli) border, PAS positive Nucleus: central or near base Lateral cell borders: indistinct (cell borders interdigitate) Lumen: small |
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What EM features are present in the thick ascending limb of the distal tubule - thick ascending limb?
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Microvilli sparse, basal infolding of plasma membrane deep, extensive and associated with high enzyme content; mitochondria long rod shaped, intimate relationship with basal infolding, apical vesicles
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What is the function of the thick ascending limb of the distal tubule?
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Energy dependent transport: K+, Na+, Cl-
Impervious to water (ountercurrent multiplier) Produce Tamm Horsfall protein (function?) |