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21 Cards in this Set
- Front
- Back
antacids
|
1. all decrease efficacy PPI
2. sodium bicarb: increase PUD 3. aluminum hydroxide + magnesium hydroxide = DOC 4. calcium carbonate: constipation |
|
H2 blocker
|
1. itidine
2. competetive block parietal cell 3. decrease gastric secretion 70% 24h 4. cimetidine + warfarin increase bleeding 5. cimetidine inhibits CYP450 |
|
PPI
|
1. -prazole
2. faster than H2 blocker 3. irreversibly inhibit 90% for 48h 4. DOC for zollinger ellison 5. prodrug that need HCl for activatin 6. some H. pylori effect |
|
prostaglandin
|
1. misoprostil
2. only use NSAID ulcer 3. C/I w/OC 4. PGE2 analog that decreases HCl 5. increase mucosal barrier via Gi |
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mucosal protective
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1. adjuncts, never monotherapy
2. need acidic pH to activate 3. interfere with absorption other Rx 4 chelated bismuth produces black tarry stool while sucralte does not |
|
quadruple therapy
|
1. PPI
2. ampicillin/tetracycline 3. clarithromycin/metronidazole 4. chelated bismuth |
|
bulk laxative
|
1. psyllium, bran, methycellulose, fiber
2. indigestible 3. C/I in stool impaction |
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saline/osmotic laxative
|
1. presurgery, poisoning, impaction
2. contraindicated in volume overload (CHF) 3. work 1-3h 4. NaPO4, lactulose, Mg-salt, PE glycol |
|
1. stool softner/surfactant
|
1. lubricate stool
2. docustate, mineral oil, glycerin suppository |
|
irritant/stimulant laxative
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1. not for elderly or non-healthy
2. castor, sena, bisocodyl, lubriprostone |
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loperamide
|
1. use diarrhea (cholera, some ecoli)
2. increase transit time 3. stim opoid receptors 4. poor CNS penetration 5. toxic megacolin if used in IBD |
|
scopalamine
|
1. M1 antagonist
2. #1 OTC 3. C/I liver/renal dz, prostatitis, dysuria |
|
5-HT3 antagonist
|
1. ondansetron, granisetron
2. work seconds, safe 3. cleared by kidney |
|
phenothiazines
|
1. promethazine: H1 antagonist
2. prochlorperazine: D2 antagonist 3. antipsychotic meds w/neuroleptic SA 4. C/I liver dz, prostatitis, glaucoma |
|
IBD
|
1. aminosalicylates
2. corticosteriod 3. thiopurine (azathiopurine, mercaptopurine) 4. methotrexate 5. cyclosporin 6. infliximab |
|
aminosalicylates
|
1. cautionn renal, pregnancy, and breast feeding
2. may decrease colorectal caner 3. may cause pancreatitis |
|
prednisone
|
1. decrease IL transcription
2. lymphocyte apoptosis 3. decrease AA metabolism |
|
thiopurine
|
1. azathiopurine and mercaptopurine (chemo)
2. leucopenia 3. use w/steriod 4. t cell apoptosis, decrease ribonucleotides |
|
methotrexate
|
1. use crohns when AZA cant be used
2. inhibit dihydrofolate reductase 3. decrease cytokines and eicosanoid synthesis |
|
cyclosporin
|
1. prevent t cell clonal expansion
2. steriod sparing 3. renal impariment, neurotoxicity |
|
infliximab
|
1. mAb to TNF
2. may reactivate TB 3. IV q 4-6w |