Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
62 Cards in this Set
- Front
- Back
what is the mechanism of action for all steroids (for now)
|
nuclear receptors that regulate gene expression
antiinflammatory inhibits COX2 decreases cytokines decreased endogenous mediators of inflammation apoptosis of eosinophils |
|
cortizone 10
|
hydrocortisone
|
|
prednisone
|
sterapred
|
|
cultivate, flovent
|
fluticasone
|
|
betamethasone
|
cerestone
|
|
name five steroid drugs
|
betamethasone
dexamethasone prednisone hydrocortison fluticasone |
|
what do u use hydrocortisone for
|
asthma
|
|
what is salmeterol
|
advair
formulation of fluticasone |
|
TX using hydrocortisone
|
anaphylaxis, ashtma, COPD, IBD, rheumatic disorders, dermatoses, replacement
|
|
TX using prednisone
|
autoimmune
allograft refjection asthma IBD RA |
|
uses of fluticasone
|
dermatoses
allergic and non allergic rhinitis |
|
can you use fluticasone for dermatoses?
|
yes
|
|
which steroids work for IBD and RA?
|
hydrocortisone
prednisone |
|
what are side effects common to all steroids we know
|
cataracts
glaucoma opportunitstic or pre existing infections |
|
which steroid uses cyp3A4
|
fluticasone and prednisone
|
|
list the side effects of prednisone
|
CNS: headaches, insomnia, vertigo, depression, anxiety, personality chagnes, psychosis
GI: NVD, anorexia, gastritis, cataracts |
|
what is special about prednisone metabolism
|
must be metabolized by 3A4 to active metabolite prednisolone
|
|
what are the indications for NSAIDs
|
analgesia
antipyretic inflammatory pain |
|
how do NSAIDS work
|
inhibit COX to decreas PG and TXA
|
|
what are the effects of PG and TXA that NSAIDS hope to block
|
pain
platelet aggregation |
|
what is asiprin an example of?
|
ion trapping
aero order kinetics |
|
whta are side effects of NSAIDs in nearly 40% of pts
|
nausea
heartburn dyspepsia abdominal pain |
|
what increases risks of side effects of NSAIDS
|
age
GI history antigoagulatnts SSRIs |
|
what two diseases are associated with aspirin
|
reyes
hypersensitivy |
|
which NSAID is irreversible? what are the rest?
|
aspirin
reversible inhibitors |
|
T or F. all nsaids may be given orally
|
true
|
|
what NSAIDS are avail OTC
|
ketoprofen
ibuprofen aspirin naproxen |
|
what is the only NSAID not implcated for serious CV risks?
|
naproxen
|
|
what is the most prescribe NSAID in the world
|
diclofenac
|
|
what are indications for diclofenac
|
osteoarthritis pain
|
|
what is sprix
|
ketorolac nasal formulation
|
|
what NSAIDS do you need to know
|
aspirin
nonacetylated salicylates ibuprofen keotprofen naproxen diclofenac ketorolac celecoxib |
|
which NSAID is selective inhibitor of COX2 only
|
celecoxib
|
|
which NSAID could you Rx pre-op
|
celecoxib
|
|
what is a risk of celecoxib
|
stevens johnson
|
|
which COX do platelets have
|
COX1 so selective COX2 will have no effect
|
|
alprostadil =
|
caverject
|
|
what prostanoids do you need to know
|
alprostadil
latanoprost midoprostol |
|
what are indicatios for alprostadil
|
ED or surgery needed in neonates
|
|
what is alprostadil a syntehtic of?
|
PGE1 agonist at EP
|
|
T or F. all the prostanoid we talked about are antagonists.
|
FALSE agonist
|
|
what do you tx glaucoma with
|
latanoprost
|
|
latanoprost -
|
xalatan
|
|
what receptor works in latanoprost
|
FP
|
|
what are indications for misoprostol
|
stomach ulcers
unwanted pregnancy |
|
what do you follow mifepristone with
|
misoprostol for early PG termination
|
|
what preg X risk drug do you know
|
misoprostol
|
|
what are indications for zileuton
|
asthma
|
|
how does zileuton work
|
5LOX inhibitor
|
|
what metabolizes zileuton
|
1A2
2C9 3A4 |
|
what do you need to monitor with zileuton
|
LFTS every 2-3 months
|
|
T or F. all the leukotriene agents are protein bound
|
true
|
|
what is the difference between zafirlukas and montelukast
|
feces
bile |
|
what are indications for montelukast and zafirlukast
|
asthma
allergic rhinitis |
|
what metabolizes both zafirlukast and montelukast
|
3A4
2C9 |
|
add ______ if you have to prescribe celecoxib for extended periods or to persons with increased risk of thrombotic events
|
low dose aspirin
|
|
avoid ____ to benefit from the protective effect of celecoxib on the gut
|
aspirin
|
|
____ intereferes with the cadioprotectic effect of low dose aspirin
|
ibuprofen
|
|
what leuko agents do you need to know
|
montelukast
zafirlukast zileuton |
|
singulair =
|
montelukast
|
|
accolade =
|
zafirlukast
|
|
zyflow =
|
zileuton
|