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32 Cards in this Set
- Front
- Back
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1st stage of RBC maturation |
Pronormoblast (Rubriblast) |
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Detectable level of hemoglobin synthesis (minute amount) |
Basophilic normoblast (Prorubricyte) |
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Last stage capable of mitosis |
Polychromatic normoblast (Rubricyte) |
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Later in this stage the nucleus is ejected |
Orthochromic normoblast (Metarubricyte) |
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Cytoplasm is the predominant color of hemoglobin (pink) |
Polychromatophilic erythrocyte (reticulocyte) |
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Lifespan is 120 days |
Erythrocyte |
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RBC |
METABOLIC PATHWAYS |
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Anaerobic glycolytic pathway Common enzyme being deficienct is pyruvate kinase |
Embden-Meyerhof Pathway |
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Aerobic glycolysis Reduced glutathione reduced peroxidases to water Common enzyme that is deficient is G6PD |
Hexose monophosphate pathway |
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NADPH reduces ferric iron to the ferrous state in the presence of methemoglobin reductase |
Methemoglobin reductase pathway |
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2,3 - diphosphoglycerate |
Luebering-Rapaport Shunt |
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Leukopoiesis |
Neutrophil Maturation |
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Round or oval nucleus |
Myeloblast |
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Primary granules |
Promyelocyte |
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Secondary granules, D- shaped, last stage capable of mitosis |
Myelocyte |
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Kidney shaped nucleus |
Metamyelocyte/Juvenile cells |
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Curved nucleus/sausage shaped/elongated |
Band or stab or staff |
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Hypersegmentation is seen in vit B12 defieciency |
Segmenter |
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Mitotic pool - 2-3 days Storage pool - 5-7 days Lifespan - 9-10 days from myeloblast to death |
Neutrophil |
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Maturation: 30-48 hours (60 hours) Tissue phae: macrophages: months, possibly longer, few hours (inflammatory macrophages) |
Monocyte |
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Maturation: B cell: 30-36 hours Lifespan: some live for 3-4 days, Majority live for months to years |
Lymphocyte |
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Blue cytoplasm |
Megakaryoblast |
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Blue cytoplasm |
Megakaryoblast |
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Nucleus is irregularly shaped, demarcating membrane system (DMS) |
Promegakaryocyte |
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Blue cytoplasm |
Megakaryoblast |
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Nucleus is irregularly shaped, demarcating membrane system (DMS) |
Promegakaryocyte |
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Granules become prominent |
Megakaryocyte |
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Blue cytoplasm |
Megakaryoblast |
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Nucleus is irregularly shaped, demarcating membrane system (DMS) |
Promegakaryocyte |
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Granules become prominent |
Megakaryocyte |
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Platelet shedding Gives rise to 2000-4000 platelets |
Metamegakaryocyte |
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Megakaryocytic system |
From least mature: 1. Megakaryoblast 2. Promegakaryocyte 3. Megakaryocyte 4. Metamegakaryocyte |
