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Cisplatin, carboplatin, oxaliplatin
Platinum (platinum analogs)
Cross-linked helix necklace = platinum analogs bind DNA and form intrastrand and interstrand cross-links
Crumpled crab = treat solid malignancies
Cisplatin, carboplatin, oxaliplatin side effects
Neuropathic gloves = peripheral neuropathy
Nephrotoxic purse = nephrotoxicity --> acute kidney disease
Muddy drain tube = acute tubular necrosis (muddy brown casts)
Cane = immunosuppression
Depleted bone jewelry box = myelosuppression
Amifostine
Amethyst (organic thiophosphate)
prevent cisplatin-induced nephrotoxicity
Free = stops free radicals formed by cisplatin
Saline fluids = IV saline diuresis prevents cisplatin nephrotoxicity, cheaper
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