term1 Definition1term2 Definition2term3 Definition3
Please sign in to your Google account to access your documents:
Phenothiazines
A group of drugs used to treat psychosis. (Henri Laborit, first tested with chlorpromazine)
Neuroleptic/Antipsychotic/Tranquilizer
Terms for antipsychotic drugs. We now separate into conventional antipsychotics (pre-1990s) or atypical (last ten years).
"Dirty" drugs
Drugs that block many types of receptors beyond the type you want to block.
Mechanism of Action - Antipsychotic
Initially they block D2 dopamine receptors. Then, 10-14 days later (after a "lag period") they have antipsychotic effect.
Clozapine
Produces less pseudoparkinsonism than other neuroleptics. However, may suppress white blood cell production (can be deadly). Blocks both D2 dopamine and 5HT2A serotonin receptors.
Pseudoparkinsonism
Tremors and muscular rigidity that results from medications
Agranulocytosis
Low white blood cell count of unknown origin (sometimes develops in early stages of treatment with antipsychotics)
Tardive Dyskinesia ("late-appearing abnormal movements")
Appears after years of antipsychotic drug treatment. Due to supersensitivity of the dopaminergic receptors. Rhythmic, repetitive sucking and smacking movements of lips, thrusting of tongue, and movements of arms, toes, or fingers.
Monoamine Oxidase
Enzyme involved in breakdown of serotonin, norepinephrine, and dopamine
MAOIs
Monoamine Oxidase Inhibitors: Anti-depressent that inhibits the MAO enzyme, increasing availability of serotonin, norepinephrine, and dopamine at the synapse.
MAOIs alter the normal metabolism of the dietary amino acid tyramine. If a person eats food with high tyramine content (aged cheese), hypertensive crisis (high blood pressure) will occur.
First MAOIs discovered were Iproniazid and isoniazid, which were meant to treat tuberculosis in 1952.
Need help typing ? See our FAQ (opens in new window)
Please sign in to create this set. We'll bring you back here when you are done.
Discard Changes Sign in
Please sign in to add to folders.
Sign in
Don't have an account? Sign Up »
You have created 2 folders. Please upgrade to Cram Premium to create hundreds of folders!