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Primary Response
response of body to first contact with antigen
Secondary Response
(memory response)
Response of host upon second exposure to an antigen
A more intesive response characterized by high titer of IgG
Based on presence of Memory cells
Cytokines
Signaling molecules
T cells 2 kinds
Helper T cells (CD4, Th)
Cytotoxic T cells (CD8, Tc)
Helper T cells
prodice cytokines to stimulate Tc sells, activate macrphages, and stimulate B cells
Cytotoxic T cells
Destroy target cells with perforin
antigen presenting cell (APC)
ingests, processes and displays antigens on its surface
Macrophages and dendritic cells serve as APC
Antigens are dislayed in association with a "self" molecule called MHC (major histocompatibility complex)
activated macrophages
macrophages stimulted by ingesting Ag or by cytokines
Natural killer cells
lymphocyts that destroy virusinfected cells + tumor cells
interrelationship of cell mediated and humoral immunity
although considered two seperate branches, the humoral immune system and cell-mediated system funstion in concert
T cells help stimulate B cells to produce Ab
antibody-dependent Cell-Mediated Cytotoxicity(ADCC)
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