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Aldosterone
Glucocorticoids
Sex Hormones
Increase plasma glucose concentrations
Cortisol is main glucocorticoid secreted.
Stimulus: Circadian Rhythm & Stress
Hypothalamus -> Corticotropin RH
Anterior pituitary -> Adrenocorticotropic hormon
Adrenal Cortex -> Cortisol
- (-) feedback to anterior pit and hypothalamus
Cortisol acts on:
- immune sys, liver, muscle, adipose tiss
Promotes gluconeogenesis
Catabolyzes skeletal muscle protein
Enhances lipolysis
Suppresses immune system
Causes (-) Ca balance
Influences brain fxn
Suppress immune system
Inhibits inflammatory response
- allergy response
- organ transplant
Excess gluconeogenesis
Hyperglycemia
Muscle catabolism and lipolysis (extra fat at deposited at trunk)
Secretes:
calcitonin (Ca balance)
thyroid hormones (T3 and T4)
Iodine enters thyroid cell via Na symport
Thyroglobulin enters colloid
Iodine enters colloid
Iodine added to tyrosine-> T3 and T4
Thyroglobulin back into cell w/ T3/4
T3 and T4 separate
Enter bld streem
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