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26 Cards in this Set
- Front
- Back
60.1 Which of the following neoplastic diseases is almost curable by chemotherapy: |
Choriocarcinoma |
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anticancer drug has high emetogenic potential: |
cisplatin |
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Cancer Therapy true: |
Anticancer drugs increase the risk of develo- ping leukaemias and lymphomas several years later |
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Anticancer drugs weaken host defense by |
A. Damaging respiratory and gut epithelia |
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Practically all antineoplastic drugs can produce the following toxic effects except: |
Cardiomyopathy |
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Alkylating agents exert cytotoxic action by inducing: |
Breakage of DNA strand Cross linking of DNA strands Abnormal pairing of purine and pyrimidine bases All of the above |
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Cyclophosphamide |
A. It is highly reactive and a vesicant on contact |
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The most important target of action of chlorambucil is: |
Lymhoid tissue |
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Methotrexate has the following attributes except: |
Folic acid reverses it's toxic |
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The following antineoplastic drug is a mitotic inhibitor and causes metaphase arrest: |
vincristine |
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Vinca alkaloids exert antitumor activity by: |
Inhibiting polymerization of tubulin to form intracellular microtubules |
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The following cytotoxic drug acts by inhibiting depoly- merization of tubulin and thus producing abnormal arrays of microtubules: |
Paclitaxel |
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Vincristine differs from vinblastine in the following respect(s):
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A. Its prominent adverse effect is neuropathy B. It frequently produces alopecia
C. It does not significantly depress bone marrow D. All of the above |
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What is true of docetaxel: |
It is used as a reserve drug for refractory breast and ovarian cancer |
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Topotecan |
It is a DNA topoisomerase I inhibitor which causes single strand DNA breaks It is a cell cycle specific anticancer drug |
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The characteristic toxicity of doxorubicin is: |
Cardiomyopathy |
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Thioguanine differs from mercaptopurine in that: |
It is not metabolized by xanthine oxidase It does not cause hyperuricemia |
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Patients treated with the following anticancer drug are likely to develop a disulfiram like reaction on taking alcohol: |
B. Procarbazine |
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The following is true about use of prednisolone in malignant diseases except: |
It is curative in acute childhood leukaemia |
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The following does not apply to cancer chemo- therapy: |
Each treatment with a cytotoxic drug kills a constant number of malignant cells |
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Select the cell cycle nonspecific antineoplastic drug: |
D. 5-Fluorouracil |
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Mesna is administered with cyclophosphamide and ifosphamide to: |
D. Ameliorate cystitis caused by them |
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Biological response modifiers like GM-CSF are used in conjunction with anticancer drugs for the following purpose(s): |
To hasten recovery from drug induced myelo- suppression |
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Thalidomide |
It ameliorates cancer associated cachexia |
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Select the drug which is used exclusively in organ transplantation and autoimmune diseases, but not in cancers: |
Cyclosporin |
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Cyclosporine has the following attributes except: |
It selectively suppresses humoral immunity without affecting cell mediated immunity |