Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
46 Cards in this Set
- Front
- Back
|
Rheumatoid factor is what type of antibody? |
IgM |
|
|
Sjogrens syndrome, mixed connective tissue disease, mixed cryoglobulinemia, and SLE all have... |
Rheumatoid factor |
|
|
What region is RF targeting on host antibodies? |
Fc region |
|
|
What antibody detected in ANA testing is diagnostic for SLE? |
Anti-dsDNA |
|
|
What type of cells are used in ANA tests? |
HEp-2 cells |
|
|
What titer must be achieved fir a positive ANA titer? |
>1:80 (plus correlating symptoms and labs) |
|
|
Peripheral pattern ANA =___ |
SLE |
|
|
Homogeneous ANA pattern =___ |
RA, SLE |
|
|
Speckled pattern ANA =___ |
SLE, SS |
|
|
Centrosome ANA pattern =___ |
PSS (Progressive systemic sclerosis) |
|
|
Nucleolar ANA pattern=___ |
SLE, PSS (progressively systematic sclerosis) |
|
|
RA (systemic/organ-specific) |
Systemic |
|
|
SLE (systemic/organ-specific) |
Systemic |
|
|
Scleroderma (systemic/organ specific) |
Systemic |
|
|
Dermatomyositis (systemic/organ-specific) |
Systemic |
|
|
Rheumatic fever (systemic/organ-specific) |
Systemic |
|
|
ITP (systemic/ organ-specific) |
Systemic |
|
|
AIHA (systemic/organ-specific) |
Systemic |
|
|
Graves disease (systemic/organ-specific) |
Organ specific - thyroid(increases thyroid hormone) |
|
|
Hashimoto's disease (systemic/organ-specific) |
Organ specific- thyroid (decreases thyroid hormone) |
|
|
Type 1 diabetes (systemic/ organ-specific) |
Organ-specific- pancreatic B-islet cells |
|
|
Vitiligo (systemic/ organ-specific) |
Organ specific (skin) |
|
|
Myasthenia Gravis (systemic/organ-specific) |
Organ specific (muscle) |
|
|
Multiple sclerosis (systemic/organ-specific) |
Organ specific - muscle |
|
|
Multiple sclerosis (systemic/organ-specific) |
Organ-specific- brain/spinal cord |
|
|
Addison disease (systemic/organ-specific) |
Organ specific- adrenal gland |
|
|
Pernicious anemia (systemic/organ-specific) |
Organ-specific- small intestines |
|
|
Glomerulonephritis (systemic/organ-specific) |
Organ-specific (kidney) |
|
|
Is thyroid elevated or decreased in graves disease? |
Elevated, antibodies are stimulating the thyroid receptors to produce more |
|
|
Is thyroid elevated or decreased in hashimoto's disease? |
Decreased, antibodies are destroying thyroid cells |
|
|
Hypersensitivity __: - reaction in 12-48 hrs - involves T-cells |
Type 4 |
|
|
Hypersensitivity __: - IgG/IgM - soluble antigens are bound - 3-12 hr reaction |
Type 3 |
|
|
Hypersensitivity __: -IgG/IgM - surface antigens bound (host cells) |
Type 2 |
|
|
Hypersensitivity __: - reaction within minutes - IgE - Mas cells and basophils |
Type 1 |
|
|
Rhinitis, asthma, hives, eczema, and food allergies all describe which hypersensitivity? |
Type 1 |
|
|
AIHA, good pasture syndrome, hashimoto's disease, transfusion reactions, HDFN, and ITP all describe which hypersensitivity? |
Type 2 |
|
|
Serum sickness, SLE, RA, bee stings, drug reactions, post infection, Arthur reaction, and farmers lung describes which hypersensitivity? |
Type 3 |
|
|
Allergic contact eczema, photocontact allergy, and drug exanthems all describe which hypersensitivity? |
Type 4 |
|
|
Name common causes of type 4 hypersensitivity reactions. |
Nickel, cosmetics, latex, fragrances, drugs, and hair dyes |
|
|
Name common causes of type 3 hypersensitivity reactions. |
Inhaled molds, inhaled foreign proteins, tetanus vaccine |
|
|
Name common causes of type 2 hypersensitivity reactions. |
Drugs, infections agents, autoimmune reactions |
|
|
Name common causes of type 1 hypersensitivity reactions. |
Pollen, food allergens, drugs (rare) |
|
|
Which hypersensitivity uses RIST and/or RAST for diagnosis? |
Type 1 |
|
|
Which hypersensitivity uses DAT for diagnosis? |
Type 2 and 3 |
|
|
What are the required HIV tests for blood donors? |
HIV 1/2 antibody and RNA neg (NAAT) |
|
|
What are the required HBV tests for blood donors? |
HBcAb, HBsAg, and DNA neg |
